Ligature-induced peri-implantitis in mice.
Ligature-induced peri-implantitis in mice.
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DOI：
10.1111/jre.12234
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发表时间：
2015-08
影响因子：
3.5
通讯作者：
Camargo PM
中科院分区：
文献类型：
--
作者：
Pirih FQ;Hiyari S;Barroso AD;Jorge AC;Perussolo J;Atti E;Tetradis S;Camargo PM
种植体周围炎的患病率为11- 47%，涉及种植体周围骨的破坏，并可能导致种植体丢失。缺乏对种植体周围炎发病机制的详细了解。本研究的目的是建立实验性种植体周围炎的小鼠模型。拔牙后8周，将机加工的光滑表面螺旋形钛种植体放置在C57 BL/6 J雄性小鼠左上颌磨牙愈合的牙槽骨中。通过在种植体固定装置的头部周围固定丝线来诱导种植体周围炎。种植体存活率和种植体周围骨水平通过显微计算机断层扫描（micro-CT）扫描和组织学在结扎放置12周后进行分析。结扎种植体的种植体存活率为60%（6/10），对照种植体为100%（8/8）。Micro-CT显示，与对照组相比，接受结扎并存活的种植体周围的骨丢失明显更大。影像学检查结果通过组织学和甲苯胺蓝染色证实。本研究描述了一种实验性种植体周围炎的小鼠模型，种植体周围的螺旋形钛种植体放置在无牙槽骨。这个模型应该是一个有用的工具，解剖种植体周围炎的致病机制和评估潜在的治疗干预措施。
Peri-implantitis has a prevalence of 11-47%, involves destruction of peri-implant bone, and may lead to implant loss. A detailed understanding of the pathogenesis of peri-implantitis is lacking. The objective of this study was to develop a murine model of experimental peri-implantitis. Machined, smooth surface screw-shaped titanium implants were placed in the healed alveolar bone of the left maxillary molars of C57BL/6J male mice, eight weeks after tooth extraction. Peri-implantitis was induced by securing silk ligatures around the head of the implant fixtures. Implant survival and peri-implant bone levels were analyzed by micro-computerized tomography (micro-CT) scans and histology twelve weeks after ligature placement. Implant survival was 60% (6/10) for implants with ligatures and 100% (8/8) for controls. Micro-CT revealed significantly greater bone loss around the implants that received ligatures and that survived as compared to controls. The radiographic findings were confirmed via histology and toluidine blue staining. This study describes a murine model of experimental peri-implantitis around screw-shaped titanium implants placed in the edentulous alveolar bone. This model should be a useful tool to dissect pathogenic mechanisms of peri-implantitis and evaluate potential treatment interventions.
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影响因子：
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作者：
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