Evaluation of training dose in male Sprague-Dawley rats trained to discriminate 4-methylmethcathinone.
Evaluation of training dose in male Sprague-Dawley rats trained to discriminate 4-methylmethcathinone.
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DOI：
10.1007/s00213-017-4716-4
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发表时间：
2017-11
影响因子：
3.4
通讯作者：
Baker LE
中科院分区：
文献类型：
--
作者：
Berquist MD 2nd;Thompson NA;Baker LE
Although the synthetic cathinone 4-methylmethcathinone (4-MMC, mephedrone) has been a subject of intensive research investigation, the pharmacological mechanisms involved in its interoceptive stimulus effects have yet to be fully characterized. The present study employed drug discrimination methods in rats to compare the interoceptive stimulus properties of two different training doses of 4-MMC to other substances with similar pharmacological actions. Sixteen male Sprague-Dawley rats were trained to discriminate either 1.0 mg/kg (N=8) or 3.0 mg/kg (N=8) 4-MMC from saline. Substitution tests were conducted with drugs that increase extracellular monoamine levels (d-amphetamine, (+)-methamphetamine, 4-MMC, MDMA, MDPV, and (−)-cocaine), a serotonin releaser (+)-fenfluramine, and a serotonergic (5-HT2A) hallucinogen (+)-LSD. Stimulus control was established in fewer sessions in the subjects trained with 3.0 mg/kg compared to those trained with 1.0 mg/kg 4-MMC. Cocaine, MDMA, and d-amphetamine produced full substitution in the 1.0 mg/kg 4-MMC-trained rats at doses that did not decrease response rate. However, doses of test drugs that engendered >80% 4-MMC-lever selection concurrently produced rate-decreasing effects in rats trained to discriminate 3.0 mg/kg 4-MMC. These findings further characterize the interoceptive stimulus effects of 4-MMC and indicate that these effects vary little with training dose, however qualitative differences in substitutability of test drugs were observed between training groups. This study expands existing knowledge regarding the psychopharmacology of 4-MMC and the potential neurochemical substrates contributing to its subjective effects.
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影响因子：
3.4
作者：
Varner, Kurt J.;Daigle, Kyle;Weed, Peter F.;Lewis, Peter B.;Mahne, Sarah E.;Sankaranarayanan, Ananthakrishnan;Winsauer, Peter J.
通讯作者：
Winsauer, Peter J.
影响因子：
6.1
作者：
German, Christopher L.;Fleckenstein, Annette E.;Hanson, Glen R.
通讯作者：
Hanson, Glen R.
影响因子：
4.2
作者：
Lisek R;Xu W;Yuvasheva E;Chiu YT;Reitz AB;Liu-Chen LY;Rawls SM
通讯作者：
Rawls SM
影响因子：
7.3
作者：
Kehr, J.;Ichinose, F.;Yoshitake, T.
通讯作者：
Yoshitake, T.
影响因子：
3.1
作者：
Karlsson, Louise;Andersson, Mikael;Kugelberg, Fredrik C.
通讯作者：
Kugelberg, Fredrik C.