The Microbiota-Gut-Brain Axis and Alzheimer's Disease: Neuroinflammation Is to Blame?
The Microbiota-Gut-Brain Axis and Alzheimer's Disease: Neuroinflammation Is to Blame?
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DOI：
10.3390/nu13010037
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发表时间：
2020-12-24
期刊：
影响因子：
5.9
通讯作者：
Burokas A
中科院分区：
文献类型：
--
作者：
Megur A;Baltriukienė D;Bukelskienė V;Burokas A
多年来，据报道，阿尔茨海默病（AD）是痴呆症最常见的原因。各种外部和内部因素可能有助于AD的早期发病。本文综述了微生物群-肠-脑（MGB）轴紊乱对AD发生发展的影响。肠道微生物群组成的改变由肠道屏障的渗透性增加和免疫细胞活化决定，导致血脑屏障功能受损，从而促进神经炎症、神经元损失、神经损伤和最终AD。许多研究表明，肠道微生物群在大脑功能和个体行为变化以及细菌淀粉样蛋白的形成中起着至关重要的作用。由肠道微生物群合成的脂多糖和细菌淀粉样蛋白可以触发驻留在大脑中的免疫细胞，并可以激活导致神经炎症的免疫反应。越来越多的实验和临床数据表明肠道生态失调和微生物-宿主相互作用在AD中的突出作用。用抗生素或益生菌补充剂调节肠道微生物群可能会为AD创造新的预防和治疗选择。越来越多的证据表明，研究MGB参与AD的机制对于寻找新的治疗靶点和治疗方法是必要的。
For years, it has been reported that Alzheimer’s disease (AD) is the most common cause of dementia. Various external and internal factors may contribute to the early onset of AD. This review highlights a contribution of the disturbances in the microbiota–gut–brain (MGB) axis to the development of AD. Alteration in the gut microbiota composition is determined by increase in the permeability of the gut barrier and immune cell activation, leading to impairment in the blood–brain barrier function that promotes neuroinflammation, neuronal loss, neural injury, and ultimately AD. Numerous studies have shown that the gut microbiota plays a crucial role in brain function and changes in the behavior of individuals and the formation of bacterial amyloids. Lipopolysaccharides and bacterial amyloids synthesized by the gut microbiota can trigger the immune cells residing in the brain and can activate the immune response leading to neuroinflammation. Growing experimental and clinical data indicate the prominent role of gut dysbiosis and microbiota–host interactions in AD. Modulation of the gut microbiota with antibiotics or probiotic supplementation may create new preventive and therapeutic options in AD. Accumulating evidences affirm that research on MGB involvement in AD is necessary for new treatment targets and therapies for AD.
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DOI：
10.3233/jad-160388
发表时间：
2016-06-27
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Allen HB
通讯作者：
Allen HB
人类肠道微生物群：与痴呆症发展的联系
影响因子：
21.1
作者：
Alkasir R;Li J;Li X;Jin M;Zhu B
通讯作者：
Zhu B
DOI：
10.1007/s10096-013-2045-z
发表时间：
2014-07-01
影响因子：
4.5
作者：
Alonso, R.;Pisa, D.;Carrasco, L.
通讯作者：
Carrasco, L.
影响因子：
4.8
作者：
Akbari E;Asemi Z;Daneshvar Kakhaki R;Bahmani F;Kouchaki E;Tamtaji OR;Hamidi GA;Salami M
通讯作者：
Salami M
影响因子：
6.8
作者：
Allen AP;Hutch W;Borre YE;Kennedy PJ;Temko A;Boylan G;Murphy E;Cryan JF;Dinan TG;Clarke G
通讯作者：
Clarke G