In Search of the Most Reproducible Neural Vulnerability Factors that Predict Future Weight Gain: Analyses of Data from Six Prospective Studies.
In Search of the Most Reproducible Neural Vulnerability Factors that Predict Future Weight Gain: Analyses of Data from Six Prospective Studies.
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DOI：
10.1093/scan/nsab013
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发表时间：
2021-01-30
影响因子：
4.2
通讯作者：
Stice, Eric
中科院分区：
文献类型：
--
作者：
Yokum, Sonja;Gearhardt, Ashley N.;Stice, Eric
我们测试了我们是否可以复制纹状体和外侧眶额皮质（OFC）对高热量食物刺激的反应与体重增加的主效应关系，这些反应在过去的论文中报道，在六个前瞻性数据集中使用了类似的功能性MRI（fMRI）范式。研究1的参与者（N = 37; M（平均）年龄= 15.5），研究2（N = 160; M年龄= 15.3），研究3（N = 130; M年龄= 15.0），研究4（N = 175; M年龄= 14.3），研究5（N = 45; M年龄= 20.8）和研究6（N = 49; M年龄= 31.1）在基线时完成了功能磁共振成像扫描，并在基线时测量了他们的体重指数（BMI）和体脂。（仅研究4和6）在基线和随访期间测量。在研究1和6中，纹状体对可口食物图像的反应升高预测BMI增加，在研究6中预测体脂增加。在6项研究中，外侧眶额皮层激活不能预测体重增加。结果提供有限的支持的假设，提高奖励区域的反应可口的食物图像预测体重增加。复制困难的因素进行了讨论，并考虑潜在的解决方案。
We tested if we could replicate the main effect relations of elevated striatum and lateral orbitofrontal cortex (OFC) response to high-calorie food stimuli to weight gain reported in past papers in six prospective datasets that used similar functional MRI (fMRI) paradigms. Participants in Study 1 (N = 37; M (mean) age = 15.5), Study 2 (N = 160; M age = 15.3), Study 3 (N = 130; M age = 15.0), Study 4 (N = 175; M age = 14.3), Study 5 (N = 45; M age = 20.8) and Study 6 (N = 49; M age = 31.1) completed fMRI scans at the baseline and had their body mass index (BMI) and body fat (Studies 4 and 6 only) measured at the baseline and over follow-ups. Elevated striatal response to palatable food images predicted BMI gain in Studies 1 and 6 and body fat gain in Study 6. Lateral OFC activation did not predict weight gain in any of the six studies. The result provide limited support for the hypothesis that elevated reward region responsivity to palatable food images predicts weight gain. Factors that make replication difficult are discussed and potential solutions considered.
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影响因子：
5.7
作者：
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通讯作者：
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