Nasal transmission of equine parvovirus hepatitis.
Nasal transmission of equine parvovirus hepatitis.
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DOI：
10.1111/jvim.16569
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发表时间：
2022-11
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
--
作者：
马细小病毒性肝炎(EqPV-H)高度流行，可引起亚临床至致命性肝炎，可在暴发时发生。虽然医源性传播有很好的记录，但水平传播的方式尚不清楚。该病毒通过鼻腔、口腔和粪便分泌物传播，据报道，PO在一匹马中传播。在更大的队列中调查PO和EqPV-H鼻腔传播的有效性。前瞻性实验传播学研究。对11匹EqPV-H阴性马接种5 × 10 6基因组等价物，每周和每月分别进行血清聚合酶链式反应和血清学检测。马先接种PO，8周后鼻腔接种PO，8周后 。在PO接种后8 周内，无一匹马转为病毒感染或血清转换。鼻腔接种后，5匹马在6~12 周内转为病毒感染，10~19 周内血清转阴。在接种后12~19 周无监测后，19~22 周又发现5匹马感染病毒。第二组5匹马可能是由于同居而从第一组5匹马开始水平传播感染的。我们证实了EqPV-H可以通过鼻腔传播。在可检测到的病毒血症之前延长的日食阶段表明，控制传播的生物安全措施可能是不切实际的。
Equine parvovirus hepatitis (EqPV‐H) is highly prevalent and causes subclinical to fatal hepatitis, which can occur in outbreaks. Whereas iatrogenic transmission is well documented, the mode of horizontal transmission is not known. The virus is shed in nasal, oral and fecal secretions, and PO transmission has been reported in a single horse. Investigate the efficiency of PO and nasal transmission of EqPV‐H in a larger cohort. Prospective experimental transmission study. Eleven EqPV‐H‐negative horses were inoculated with 5 × 106 genome equivalents EqPV‐H. Serum PCR and serology for EqPV‐H were performed weekly and monthly, respectively. Horses first were inoculated PO, and then intranasally 8 weeks later. No horse became viremic or seroconverted within 8 weeks after PO inoculation. After intranasal inoculation, 5 horses became viremic within 6 to 12 weeks and seroconverted within 10 to 19 weeks. After a period without monitoring from 12 to 19 weeks postinoculation, another 5 horses were found to be viremic at 19 to 22 weeks. The second set of 5 horses could have been infected by horizontal transmission from the first 5 because of cohousing. We demonstrated that EqPV‐H can be transmitted nasally. The prolonged eclipse phase before detectable viremia indicates biosecurity measures to control spread could be impractical.
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DOI：
10.4049/jimmunol.1601775
发表时间：
2017-07-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Boyaka PN
通讯作者：
Boyaka PN
影响因子：
4.7
作者：
Altan, Eda;Li, Yanpeng;Delwart, Eric
通讯作者：
Delwart, Eric
影响因子：
32.4
作者：
Obermoser, Gerlinde;Presnell, Scott;Chaussabel, Damien
通讯作者：
Chaussabel, Damien
接种普通生物产物后，新的细小病毒与马匹中的血清肝炎有关。
影响因子：
11.8
作者：
Divers TJ;Tennant BC;Kumar A;McDonough S;Cullen J;Bhuva N;Jain K;Chauhan LS;Scheel TKH;Lipkin WI;Laverack M;Trivedi S;Srinivasa S;Beard L;Rice CM;Burbelo PD;Renshaw RW;Dubovi E;Kapoor A
通讯作者：
Kapoor A
影响因子：
5.5
作者：
Gildea, Sarah;Quinlivan, Michelle;Cullinane, Ann
通讯作者：
Cullinane, Ann