Dietary advanced glycation end products and aging.
Dietary advanced glycation end products and aging.
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DOI：
10.3390/nu2121247
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发表时间：
2010-12
期刊：
影响因子：
5.9
通讯作者：
Chapman-Novakofski K
中科院分区：
文献类型：
--
作者：
Luevano-Contreras C;Chapman-Novakofski K
晚期糖基化终末产物(AGEs)是一组多相、复杂的化合物，当还原糖以非酶方式与蛋白质和其他大分子中的氨基酸反应时形成。这既发生在外源性(食物中)，也发生在内源性(人类)，在老年人中发现更高的浓度。虽然健康的老年人和患有慢性病的人都会出现年龄较高的情况，但研究正在取得进展，以量化食物和人体中的年龄，并找出可以解释为什么一些人体组织受损，而另一些组织没有受损的机制。在过去的二十年里，越来越多的证据表明，AGEs可能与慢性退行性老年疾病的发展有关，如心血管疾病、阿尔茨海默病和糖尿病并发症。在动物模型和人类中进行的几项研究结果表明，限制饮食年龄对伤口愈合、胰岛素抵抗和心血管疾病有积极影响。最近，在动物模型中，限制AGE摄入量的效果被报道为延长寿命。本文将总结已发表的关于食物年龄和活体年龄的工作及其与衰老的关系，并对未来的研究提出建议。
Advanced glycation end products (AGEs) are a heterogeneous, complex group of compounds that are formed when reducing sugar reacts in a non-enzymatic way with amino acids in proteins and other macromolecules. This occurs both exogenously (in food) and endogenously (in humans) with greater concentrations found in older adults. While higher AGEs occur in both healthy older adults and those with chronic diseases, research is progressing to both quantify AGEs in food and in people, and to identify mechanisms that would explain why some human tissues are damaged, and others are not. In the last twenty years, there has been increased evidence that AGEs could be implicated in the development of chronic degenerative diseases of aging, such as cardiovascular disease, Alzheimer’s disease and with complications of diabetes mellitus. Results of several studies in animal models and humans show that the restriction of dietary AGEs has positive effects on wound healing, insulin resistance and cardiovascular diseases. Recently, the effect of restriction in AGEs intake has been reported to increase the lifespan in animal models. This paper will summarize the work that has been published for both food AGEs and in vivo AGEs and their relation with aging, as well as provide suggestions for future research.
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影响因子：
4.5
作者：
Choi, Su-Yeon;Chang, Hyuk-Jae;Kim, Mi-Hyang
通讯作者：
Kim, Mi-Hyang
DOI：
10.1093/gerona/gln018
发表时间：
2009-01
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Dalal M;Ferrucci L;Sun K;Beck J;Fried LP;Semba RD
通讯作者：
Semba RD
影响因子：
4.7
作者：
Diamanti-Kandarakis, Evanthia;Piperi, Christina;Papavassiliou, Athanasios G.
通讯作者：
Papavassiliou, Athanasios G.
影响因子：
4.2
作者：
Bär, KJ;Franke, S;Sauer, H
通讯作者：
Sauer, H
DOI：
10.1097/01.mco.0000171129.29278.26
发表时间：
2006-01-01
影响因子：
3.1
作者：
Bengmark, S
通讯作者：
Bengmark, S