Hippocampal-cortical coupling differentiates long-term memory processes.
Hippocampal-cortical coupling differentiates long-term memory processes.
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DOI：
10.1073/pnas.2207909120
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发表时间：
2023-02-14
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
--
作者：
长期记忆是动态的，但使这种行为灵活性得以实现的网络模式还没有得到很好的理解。在目前的研究中，我们发现海马体和皮层的活动根据年龄、强度和记忆类型的不同而有不同的协调。我们的发现可能有助于识别不同正在进行的记忆过程的标记，并理解导致信息保留受损和过度活跃的机制。长期记忆的重新激活使经验依赖的记忆痕迹得到加强、减弱或更新。尽管海马体和皮层活动模式的耦合促进了初始记忆巩固，但这些模式是否以及如何参与激活后的记忆过程尚不清楚。在这里，当大鼠重复学习和检索空间和非空间记忆时，我们监测了海马体-皮层网络。研究表明，海马尖波涟漪（SPW-R）、皮质纺锤波（SPI）和皮质涟漪（CXR）之间的相互作用在没有记忆需求的情况下是共同调节的，但根据记忆阶段和任务类型独立募集。与最初的巩固相比，检索后的记忆再巩固与海马spw - r和cxr之间的耦合窗口增加和延长有关。海马SPW-R和皮层纺锤体的相互作用在记忆巩固过程中优先参与。这些发现表明，特定的、有时间限制的振荡耦合模式可以支持在动态环境中灵活管理长期记忆所需的独特记忆过程。
Long-term memories are dynamic, but the network patterns that enable this behavioral flexibility are not well understood. In the present study, we show that activity in the hippocampus and cortex is differentially coordinated based on the age, strength, and type of memory. Our findings may be useful in identifying markers of different ongoing memory processes and understanding mechanisms that lead to both impaired and overactive information retention. Reactivation of long-term memories enables experience-dependent strengthening, weakening, or updating of memory traces. Although coupling of hippocampal and cortical activity patterns facilitates initial memory consolidation, whether and how these patterns are involved in postreactivation memory processes are not known. Here, we monitored the hippocampal–cortical network as rats repetitively learned and retrieved spatial and nonspatial memories. We show that interactions between hippocampal sharp wave–ripples (SPW-R), cortical spindles (SPI), and cortical ripples (CXR) are jointly modulated in the absence of memory demand but independently recruited depending on the stage of memory and task type. Reconsolidation of memory after retrieval is associated with an increased and extended window of coupling between hippocampal SPW-Rs and CXRs compared to the initial consolidation. Hippocampal SPW-R and cortical spindle interactions are preferentially engaged during memory consolidation. These findings suggest that specific, time-limited patterns of oscillatory coupling can support the distinct memory processes required to flexibly manage long-term memories in a dynamic environment.
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影响因子：
25
作者：
Dupret, David;O'Neill, Joseph;Pleydell-Bouverie, Barty;Csicsvari, Jozsef
通讯作者：
Csicsvari, Jozsef
DOI：
10.1126/science.aan6203
发表时间：
2017-10-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Khodagholy D;Gelinas JN;Buzsáki G
通讯作者：
Buzsáki G
影响因子：
56.9
作者：
Frankland, PW;Bontempi, B;Silva, AJ
通讯作者：
Silva, AJ
影响因子：
25
作者：
Girardeau, Gabrielle;Benchenane, Karim;Zugaro, Michael B.
通讯作者：
Zugaro, Michael B.
影响因子：
13.6
作者：
Jastrzebska-Perfect, Patricia;Spyropoulos, George D.;Khodagholy, Dion
通讯作者：
Khodagholy, Dion