What makes Xanthomonas albilineans unique amongst xanthomonads?

What makes Xanthomonas albilineans unique amongst xanthomonads?
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DOI:
10.3389/fpls.2015.00289
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发表时间:
2015
影响因子:
5.6
通讯作者:
Cociancich S
Cociancich S
中科院分区:
生物学2区
文献类型:
--
作者:
Pieretti I;Pesic A;Petras D;Royer M;Süssmuth RD;Cociancich S

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白纹黄单胞菌引起甘蔗的一种致死性病害--叶枯病。与黄单胞菌属的其它种类相比,X. albilineans具有独特的致病机制,生态学和分类学。它的基因组经历了严重的侵蚀,具有独特的基因组特征。它缺乏黄单胞菌属其他植物致病性物种致病性所需的两个位点:黄原胶生物合成和Hrp-T3 SS(hypersensitiveresponseandpathogenicity-typethreeselectionsystem)基因簇。相反,X. albilineans在其基因组中具有通常在动物病原体中发现的SPI-1(沙门氏菌致病岛-1)T3 SS基因簇。X.白叶枯病菌产生一种称为albicidin的有效DNA促旋酶抑制剂,其阻断叶绿体分化,导致特征性的白色叶条纹症状。albicidin对X.在甘蔗定殖过程中,albilineans对竞争对手的细菌具有竞争优势。最近的化学研究揭示了albicidin的独特结构,并使我们能够部分阐明其迷人的生物合成装置,其中涉及一个神秘的混合PKS/NRPS(聚酮合酶/非核糖体肽合成酶)机制。
Xanthomonas albilineans causes leaf scald, a lethal disease of sugarcane. Compared to other species of Xanthomonas, X. albilineans exhibits distinctive pathogenic mechanisms, ecology and taxonomy. Its genome, which has experienced significant erosion, has unique genomic features. It lacks two loci required for pathogenicity in other plant pathogenic species of Xanthomonas: the xanthan gum biosynthesis and the Hrp-T3SS (hypersensitive response and pathogenicity-type three secretion system) gene clusters. Instead, X. albilineans harbors in its genome an SPI-1 (Salmonella pathogenicity island-1) T3SS gene cluster usually found in animal pathogens. X. albilineans produces a potent DNA gyrase inhibitor called albicidin, which blocks chloroplast differentiation, resulting in the characteristic white foliar stripe symptoms. The antibacterial activity of albicidin also confers on X. albilineans a competitive advantage against rival bacteria during sugarcane colonization. Recent chemical studies have uncovered the unique structure of albicidin and allowed us to partially elucidate its fascinating biosynthesis apparatus, which involves an enigmatic hybrid PKS/NRPS (polyketide synthase/non-ribosomal peptide synthetase) machinery.
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