In vivo optic nerve head mechanical response to intraocular and cerebrospinal fluid pressure: imaging protocol and quantification method.
In vivo optic nerve head mechanical response to intraocular and cerebrospinal fluid pressure: imaging protocol and quantification method.
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DOI：
10.1038/s41598-018-31052-x
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发表时间：
2018-08-23
影响因子：
4.6
通讯作者：
Girkin CA
中科院分区：
文献类型：
--
作者：
Fazio MA;Clark ME;Bruno L;Girkin CA
本研究提出了一种定量评估急性眼内压（IOP）升高和脑脊液压力（CSFP）随体位变化下活体人眼视神经乳头（ONH）变形的方法。在急性IOP和CSFP升高试验期间，通过光学相干断层扫描血管造影术对患有开角型青光眼的脑死亡器官供体的一只眼睛进行成像。通过数字体积相关计算体积3D应变。随着IOP的增加，坐位和仰卧位的剪切应变一致地增加（p < 0.001）。当通过改变体位在恒定IOP下增加CSFP时，观察到ONH应变的整体降低（-0.14%p = 0.0264）。血管系统中的应变显著高于结构组织中的应变（+0.90%，p = 0.0002）。视网膜神经纤维层（RNFL）厚度与视乳头周围巩膜（ppScl）的应变密切相关（ρ =-0.847，p = 0.008），但与视网膜（p = 0.433）和椎板（p = 0.611）无关。这些初步结果表明：CSFP独立于IOP调节人ONH中的应变; ppScl应变大于板层和视网膜中的应变;视网膜血管系统中的应变高于结构组织中的应变;在该青光眼眼中，较高的ppScl应变与较低的RNFL厚度相关。
This study presents a quantification method for the assessment of the optic nerve head (ONH) deformations of the living human eye under acute intraocular pressure (IOP) elevation and change of cerebrospinal fluid pressure (CSFP) with body position. One eye from a brain-dead organ donor with open-angle glaucoma was imaged by optical coherence tomography angiography during an acute IOP and CSFP elevation test. Volumetric 3D strain was computed by digital volume correlation. With increase in IOP the shear strain consistently increased in both sitting and supine position (p < 0.001). When CSFP was increased at constant IOP by changing body position, a global reduction in the ONH strain was observed (−0.14% p = 0.0264). Strain in the vasculature was significantly higher than in the structural tissue (+0.90%, p = 0.0002). Retinal nerve fiber layer (RNFL) thickness strongly associated (ρ = −0.847, p = 0.008) with strain in the peripapillary sclera (ppScl) but not in the retina (p = 0.433) and lamina (p = 0.611). These initial results show that: CSFP independently to IOP modulates strain in the human ONH; ppScl strains are greater than strains in lamina and retina; strain in the retinal vasculature was higher than in the structural tissue; In this glaucoma eye, higher ppScl strain associated with lower RNFL thickness.
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影响因子：
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通讯作者：
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