Cord serum brain-derived neurotrophic factor levels at birth associate with temperament outcomes at one year.
Cord serum brain-derived neurotrophic factor levels at birth associate with temperament outcomes at one year.
复制标题
DOI：
10.1016/j.jpsychires.2022.03.009
复制
发表时间：
2022-06
影响因子：
4.8
通讯作者：
John, Rosalind M.
中科院分区：
文献类型：
--
作者：
Dingsdale, Hayley;Garay, Samantha M.;Tyson, Hannah R.;Savory, Katrina A.;Sumption, Lorna A.;Kelleher, Jemima S.;Langley, Kate;Van Goozen, Stephanie;John, Rosalind M.
脑源性神经营养因子（BDNF）的血清水平变化始终与神经系统疾病有关。BDNF也越来越多地参与神经发育障碍的发病机制，特别是那些在男性中更常见的神经发育障碍。在出生时，男婴的血清BDNF水平明显较低（比女婴低10-20%），这可能使他们更容易患上神经发育障碍。我们以前的特点是血清BDNF水平的母亲和他们的新生儿作为威尔士研究的一部分。在这里，我们分析了出生时脐带血清BDNF水平是否与一年后的性别特异性结局相关。使用贝利婴儿发育量表第三版（BSID-III）和实验室气质评估组合（Lab-TAB）任务评估12-14个月时的婴儿行为和神经发育（平均值± SD：13.3 ± 1.6个月; 46%男性; n = 56）。我们发现出生时血清BDNF水平与BSID-III神经发育结果（认知或语言）之间没有关系，也与Lab-TAB不可预测的机械玩具或母亲分离任务中的婴儿行为无关。在持续注意力任务中，血清BDNF和婴儿负面情绪之间存在显著的正相关关系（B = 0.06，p = 0.018），仅对于男孩，血清BDNF和面部兴趣强度之间存在显著的正相关关系（B = 0.03，p = 0.005）。然而，经过多次测试校正后，只有后者仍然存在。脐带血清BDNF和12-14个月注意力参数之间的性别特异性相关性为出生时血清BDNF水平降低与神经发育障碍风险增加有关的假设提供了一些支持。BDNF与神经发育障碍有关，在男性中更常见男婴出生时血清BDNF较低;这可能是导致风险较高的因素出生时血清BDNF与1岁时的认知或语言结果无关仅在男性中，血清BDNF与注意力的面部兴趣呈正相关出生时血清BDNF可能与神经发育障碍的风险相关
Altered serum levels of brain-derived neurotrophic factor (BDNF) are consistently linked with neurological disorders. BDNF is also increasingly implicated in the pathogenesis of neurodevelopmental disorders, particularly those found more frequently in males. At birth, male infants naturally have significantly lower serum BDNF levels (∼10–20% lower than females), which may render them more vulnerable to neurodevelopmental disorders. We previously characterized serum BDNF levels in mothers and their newborn infants as part of the Grown in Wales Study. Here, we analyzed whether cord serum BDNF levels at birth correlate with sex-specific outcomes at one year. The Bayley Scale of Infant Development, Third Edition (BSID-III) and Laboratory Temperament Assessment Battery (Lab-TAB) tasks were used to assess infant behavior and neurodevelopment at 12–14 months (mean ± SD: 13.3 ± 1.6 months; 46% male; n = 56). We found no relationship between serum BDNF levels at birth and BSID-III neurodevelopmental outcomes (cognitive or language), nor with infant behaviors in the Lab-TAB unpredictable mechanical toy or maternal separation tasks. In the sustained attention task, there was a significant positive relationship between serum BDNF and infant negative affect (B = 0.06, p = 0.018) and, for boys only, between serum BDNF and intensity of facial interest (B = 0.03, p = 0.005). However, only the latter remained after correction for multiple testing. This sex-specific association between cord serum BDNF and a parameter of attention at 12–14 months provides some support for the hypothesis that reduced serum BDNF levels at birth are linked to an increased risk for neurodevelopmental disorders. BDNF is implicated in neurodevelopmental disorders more frequently seen in males Male infants have lower serum BDNF at birth; this may factor into higher risk Serum BDNF at birth was not linked to cognitive or language outcomes at 1 year In males only, serum BDNF positively associated with facial interest in attention Serum BDNF at birth may associate with risks for neurodevelopmental disorders
登录
查看更多内容
影响因子：
6.8
作者：
Dingsdale H;Nan X;Garay SM;Mueller A;Sumption LA;Chacón-Fernández P;Martinez-Garay I;Ghevaert C;Barde YA;John RM
通讯作者：
John RM
影响因子：
4.6
作者：
Barbosa AG;Pratesi R;Paz GSC;Dos Santos MAAL;Uenishi RH;Nakano EY;Gandolfi L;Pratesi CB
通讯作者：
Pratesi CB
DOI：
10.1016/j.pnpbp.2013.07.018
发表时间：
2013-12-02
影响因子：
5.6
作者：
Amiri, Ali;Parizi, Gholamreza Torabi;Roushan, Zahra Atrkar
通讯作者：
Roushan, Zahra Atrkar
影响因子：
15.1
作者：
Chang, Jane Pei-Chen;Mondelli, Valeria;Pariante, Carmine M.
通讯作者：
Pariante, Carmine M.
影响因子：
2.6
作者：
Cai, Qian-Ying;Zhang, Heng-Xin;Yang, Xin-Jun
通讯作者：
Yang, Xin-Jun