Dimer targeting peptide mediated precise and controllable drug delivery by upconversion nanocarriers for breast cancer therapy
Dimer targeting peptide mediated precise and controllable drug delivery by upconversion nanocarriers for breast cancer therapy
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二聚体靶向肽通过上转换纳米载体介导精确可控的药物递送用于乳腺癌治疗
DOI：
10.1016/j.matdes.2021.109597
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发表时间：
2021-02
影响因子：
8.4
通讯作者：
Yu Yongsheng
中科院分区：
文献类型：
--
作者：
Zhang Kunyu;Wan Zhong;Jiang Huabo;Xiao Xiufeng;Feng Qian;Meng Yanchun;Yu Yongsheng
乳腺癌是女性癌症相关死亡的主要原因之一。化疗仍然是乳腺癌的主要临床治疗方法之一。然而，这种疗法有明显的副作用。纳米尺度的载体，如金属纳米颗粒和脂质体，正被广泛用作药物递送载体以实现肿瘤细胞的精确靶向。在本研究中，我们设计了一种新型的基于光不稳定帽状分子的上转换纳米载体（UCNCs）主客体络合体系。将含有表阿霉素（EPI）的UCNCs与二聚体靶向肽-环糊精-金刚烷主客体络合物接枝。在二聚体靶向肽的引导下进入乳腺肿瘤细胞后，UCNCs的核心将近红外光上转换为紫外光，随后触发表阿霉素的细胞内按需释放。表阿霉素在乳腺癌细胞内的精确和有效的递送和释放在体外显著抑制癌细胞的增殖、迁移和侵袭，并且在体内减小肿瘤尺寸。我们相信，这种UCNCs系统是一个有前途的平台，用于精确和可控地输送各种化疗药物，用于临床癌症治疗。
Breast cancer is one of the leading causes of cancer-related deaths in women. Chemotherapy remains one of the main clinical treatments for breast cancer. However, this therapy has appreciable side effects. Nanoscale carriers, such as metal nanoparticles and liposomes, are being widely utilized as drug delivery vehicles to achieve precise targeting of tumor cells. In this study, we designed a novel upconversion nanocarriers (UCNCs) host-guest complexation system based on a photolabile capping-like molecule. UCNCs containing epirubicin (EPI) were grafted with a dimer-targeting peptideviacyclodextrin-adamantine host-guest complexation. After entering breast tumor cells with the guidance of the dimer-targeting peptide, the core of the UCNCs upconverted near-infrared light to ultraviolet light which subsequently triggered the intracellular on-demand release of epirubicin. The precise and efficient delivery and release of epirubicin inside breast cancer cells significantly inhibited cancer cells proliferation, migration, and invasionin vitroand decreased the tumor sizein vivo. We believe that this UCNCs system is a promising platform for the precise and controllable delivery of various chemotherapy drugs for clinical cancer treatments.
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影响因子：
13.3
作者：
Yang, Yanmei;Velmurugan, Bhaarathy;Xing, Bengang
通讯作者：
Xing, Bengang
影响因子：
9.7
作者：
Oh, Steve;Kim, Byung Ju;Sasaki, Tomikazu
通讯作者：
Sasaki, Tomikazu
DOI：
10.1016/j.ecl.2011.05.009
发表时间：
2011-09-01
影响因子：
4.5
作者：
Germain, Doris
通讯作者：
Germain, Doris
影响因子：
8.4
作者：
Choi, Jung Eun;Kim, Hee-Kwon;Jang, Ho Seong
通讯作者：
Jang, Ho Seong
基于上转换纳米粒子的近红外光诱导体内癌症光动力疗法
影响因子：
14
作者：
Wang, Chao;Tao, Huiquan;Liu, Zhuang
通讯作者：
Liu, Zhuang