Neural correlates of extinguished threat recall underlying the commonality between pediatric anxiety and irritability.
Neural correlates of extinguished threat recall underlying the commonality between pediatric anxiety and irritability.
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DOI：
10.1016/j.jad.2021.08.117
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发表时间：
2021-12-01
影响因子：
6.6
通讯作者：
Brotman MA
中科院分区：
文献类型：
--
作者：
Tseng WL;Abend R;Gold AL;Brotman MA
焦虑和易怒经常同时发生在青年人中，并由异常的威胁反应介导。然而，这种共同发生的神经机制的经验证据是有限的。为了解决这个问题，我们应用数据驱动的潜在表型数据，从一个经过验证的威胁灭绝回忆功能磁共振成像范例的先前报告。参与者包括59名青年（28名焦虑症患者，31名健康志愿者;法师= 13.15岁），来自331名青年的跨诊断样本，其中进行双因素分析，以获得代表维度评估的焦虑和易怒的共享与独特方差的潜在因素。参与者经历了威胁条件反射和灭绝。大约三周后，在消退回忆功能磁共振成像，参与者在两个任务条件下的威胁安全的歧视：当前的威胁评估和明确的回忆威胁突发事件。线性混合效应分析研究了反映共同焦虑和易怒变化的“消极情感”因素与全脑激活和任务依赖性杏仁核连接的关联。在回忆威胁-安全意外事件时，较高的负性情感与更大的前额叶（腹外侧/腹内侧、背外侧、眶额）、运动、颞叶、顶叶和枕叶激活相关。在威胁评估，更高的负面情感与更大的杏仁核顶下小叶连接到威胁/安全的模糊性。样本仅包括健康青年和患有焦虑症的青年。结果可能无法推广到其他焦虑和易怒也很常见的诊断，我们的负性情感因素应解释为焦虑症与易怒升高。部分子因子的信度较差。异常杏仁核-前额叶-顶叶电路在灭绝回忆的威胁-安全性刺激可能是一种机制的儿童焦虑和易怒的共同发生。
Anxiety and irritability frequently co-occur in youth and are mediated by aberrant threat responses. However, empirical evidence on neural mechanisms underlying this co-occurrence is limited. To address this, we apply data-driven latent phenotyping to data from a prior report of a well-validated threat extinction recall fMRI paradigm. Participants included 59 youth (28 anxiety disorder, 31 healthy volunteers; Mage=13.15yrs) drawn from a transdiagnostic sample of 331 youth, in which bifactor analysis was conducted to derive latent factors representing shared vs. unique variance of dimensionally-assessed anxiety and irritability. Participants underwent threat conditioning and extinction. Approximately three weeks later, during extinction recall fMRI, participants made threat-safety discriminations under two task conditions: current threat appraisal and explicit recall of threat contingencies. Linear mixed-effects analyses examined associations of a “negative affectivity” factor reflecting shared anxiety and irritability variance with whole-brain activation and task-dependent amygdala connectivity. During recall of threat-safety contingencies, higher negative affectivity was associated with greater prefrontal (ventrolateral/ventromedial, dorsolateral, orbitofrontal), motor, temporal, parietal, and occipital activation. During threat appraisal, higher negative affectivity was associated with greater amygdala-inferior parietal lobule connectivity to threat/safety ambiguity. Sample included only healthy youth and youth with anxiety disorders. Results may not generalize to other diagnoses for which anxiety and irritability are also common, and our negative affectivity factor should be interpreted as anxiety disorders with elevated irritability. Reliability of some subfactors was poor. Aberrant amygdala-prefrontal-parietal circuitry during extinction recall of threat-safety stimuli may be a mechanism underlying the co-occurrence of pediatric anxiety and irritability.
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影响因子：
6.9
作者：
Abend R;Swetlitz C;White LK;Shechner T;Bar-Haim Y;Filippi C;Kircanski K;Haller SP;Benson BE;Chen G;Leibenluft E;Fox NA;Pine DS
通讯作者：
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影响因子：
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作者：
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通讯作者：
Pine, Daniel S.
影响因子：
6.9
作者：
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通讯作者：
Blair RJR
影响因子：
4.1
作者：
Dvir, Maor;Horovitz, Omer;Shechner, Tomer
通讯作者：
Shechner, Tomer
DOI：
10.1097/00004583-199704000-00018
发表时间：
1997-04-01
影响因子：
13.3
作者：
Birmaher, B;Khetarpal, S;Neer, SM
通讯作者：
Neer, SM