Functionalized Polymeric Membrane with Enhanced Mechanical and Biological Properties to Control the Degradation of Magnesium Alloy
Functionalized Polymeric Membrane with Enhanced Mechanical and Biological Properties to Control the Degradation of Magnesium Alloy
复制标题
具有增强机械和生物性能的功能化聚合物膜可控制镁合金的降解
DOI：
10.1002/adhm.201601269
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发表时间：
2017-04
影响因子：
10
通讯作者：
Yeung Kelvin W. K.
中科院分区：
文献类型：
--
作者：
Wong Hoi Man;Zhao Ying;Leung Frankie K. L.;Xi Tingfei;Zhang Zhixiong;Zheng Yufeng;Wu Shuilin;Luk Keith D. K.;Cheung Kenneth M. C.;Chu Paul K.;Yeung Kelvin W. K.
为了增强镁合金的生物响应和受控降解，通过热方法制造了一种称为聚己内酯（PCL）的改性可生物降解聚合物涂层，与未处理的样品相比，热处理既不会改变PCL膜的化学成分，也不会改变镁离子释放速率、pH值或重量损失。热处理PCL涂层结晶度、亲水性和氧含量的变化不仅提高了涂层与镁基体之间的机械附着强度，而且增强了生物性能。此外，由于亲水性和C-O与C-O官能团比的增强，热改性样品可以导致成骨细胞更高的铺展和伸长。在术后 1 至 4 周的显微计算机断层扫描分析中，热处理样品的新骨形成总量分别比未处理和未涂层对照高 10%–35% 和 70%–90%。令人惊讶的是，与热处理样品相邻的新形成骨的压痕模量比两个对照高约 20%。这些有希望的结果揭示了镁合金上改性 PCL 涂层在骨科应用中的临床潜力。
To achieve enhanced biological response and controlled degradation of magnesium alloy, a modified biodegradable polymer coating called polycaprolactone (PCL) is fabricated by a thermal approach in which the heat treatment neither alters the chemical composition of the PCL membrane nor the rate of magnesium ion release, pH value, or weight loss, compared with the untreated sample. The changes in the crystallinity, hydrophilicity, and oxygen content of heat‐treated PCL coating not only improve the mechanical adhesion strength between the coating and magnesium substrate but also enhance the biological properties. Moreover, the thermally modified sample can lead to higher spreading and elongation of osteoblasts, due to the enhanced hydrophilicity and CO to CO functional group ratio. In the analyses of microcomputed tomography from one to four weeks postoperation, the total volume of new bone formation on the heat‐treated sample is 10%–35% and 70%–90% higher than that of the untreated and uncoated controls, respectively. Surprisingly, the indentation modulus of the newly formed bone adjacent to the heat‐treated sample is ≈20% higher than that of both controls. These promising results reveal the clinical potential of the modified PCL coating on magnesium alloy in orthopedic applications.
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影响因子：
3.2
作者：
Leidi, Marzia;Dellera, Federica;Maier, Jeanette A. M.
通讯作者：
Maier, Jeanette A. M.
DOI：
10.1016/0009-8981(69)90046-1
发表时间：
1969-02
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
--
作者：
J. Pybus
通讯作者：
J. Pybus
影响因子：
14
作者：
D. Walsh;T. Furuzono;J. Tanaka
通讯作者：
D. Walsh;T. Furuzono;J. Tanaka
影响因子：
14
作者：
Sun, HF;Mei, L;Wang, PY
通讯作者：
Wang, PY
影响因子：
4.3
作者：
Sawase, Takashi;Jimbo, Ryo;Atsuta, Mitsuru
通讯作者：
Atsuta, Mitsuru