The influence of vitamin D supplementation on local and systemic inflammatory markers in periodontitis patients: A pilot study.
The influence of vitamin D supplementation on local and systemic inflammatory markers in periodontitis patients: A pilot study.
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DOI：
10.1111/odi.13097
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发表时间：
2019-07
期刊：
影响因子：
3.8
通讯作者：
Cutler CW
中科院分区：
文献类型：
--
作者：
Meghil MM;Hutchens L;Raed A;Multani NA;Rajendran M;Zhu H;Looney S;Elashiry M;Arce RM;Peacock ME;Dong Y;Cutler CW
维生素D缺乏/不足是一个全球性的公共卫生问题，与包括牙周炎在内的许多炎症性疾病有关。越来越多的人支持充足的维生素D水平对整体健康的作用。肤色较深的人群维生素D缺乏/不足和牙周炎的患病率较高。这项小型试点研究的目的是调查12周补充25(OH)D维生素D对黑皮肤牙周炎患者全身炎症介质的影响。共有23名中度至重度牙周炎患者被随机分配到维生素D组或安慰剂组，并接受强化单次洗牙和牙根刨平治疗，以引起全身炎症反应。维生素D补充剂（VDS）使血清25(OH)D水平比基线水平提高约2倍；此外，VDS组外周血CD3和CD3+CD8+细胞毒性T淋巴细胞（ctl）计数降低，唾液促炎细胞因子减少。相比之下，VDS组全血pbmc中自噬相关蛋白和其他抗微生物自噬关键蛋白的水平更高。综上所述，补充维生素D在减少全身炎症和促进诱导与抗微生物功能相关的自噬相关蛋白方面具有多重益处。
Vitamin D deficiency/insufficiency is a worldwide public health issue that has been linked to numerous inflammatory disorders, including periodontitis. There is increasing support for a role for adequate vitamin D levels in overall health. Populations with darker skin color have a higher prevalence of vitamin D deficiency/insufficiency and periodontitis. The purpose of this small pilot study was to investigate the influence of 12 weeks of 25(OH)D vitamin D supplementation on mediators of systemic inflammation in dark-skinned, periodontitis patients. A total of 23 patients with moderate to severe periodontitis were randomly assigned to the vitamin D group or Placebo group and received intensive single visit scaling and root planing to elicit a systemic inflammatory response. Vitamin D supplementation (VDS) increased serum 25(OH)D levels approximately 2-fold over baseline levels; moreover, VDS group had reduced peripheral blood CD3 and CD3+CD8+ cytotoxic T lymphocyte (CTLs) counts and reduced pro-inflammatory salivary cytokines. In contrast, VDS group had higher levels of the autophagy-related proteins and other proteins crucial for anti-microbial autophagy in whole blood PBMCs. In conclusion, vitamin D supplementation has multiple benefits for reducing systemic inflammation and promoting induction of autophagy related proteins related to anti-microbial functions.
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影响因子：
8
作者：
Dong Y;Pollock N;Stallmann-Jorgensen IS;Gutin B;Lan L;Chen TC;Keeton D;Petty K;Holick MF;Zhu H
通讯作者：
Zhu H
影响因子：
5.9
作者：
Hoe E;Nathanielsz J;Toh ZQ;Spry L;Marimla R;Balloch A;Mulholland K;Licciardi PV
通讯作者：
Licciardi PV
影响因子：
7.6
作者：
Bashutski, J. D.;Eber, R. M.;McCauley, L. K.
通讯作者：
McCauley, L. K.
影响因子：
1.6
作者：
Hiremath, Vishwanath P.;Rao, C. Bhasker;Prasad, Kakrala Veera Venkatesha
通讯作者：
Prasad, Kakrala Veera Venkatesha
影响因子：
7.1
作者：
Dietrich, T;Nunn, M;Bischoff-Ferrari, HA
通讯作者：
Bischoff-Ferrari, HA