3D mapping of elastic modulus using shear wave optical micro-elastography.
3D mapping of elastic modulus using shear wave optical micro-elastography.
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DOI：
10.1038/srep35499
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发表时间：
2016-10-20
影响因子：
4.6
通讯作者：
Chen Z
中科院分区：
文献类型：
--
作者：
Zhu J;Qi L;Miao Y;Ma T;Dai C;Qu Y;He Y;Gao Y;Zhou Q;Chen Z
弹性成像为组织病理学鉴定和基于组织硬度信息的临床诊断提供了强有力的工具。由于高分辨率、三维(3D)和非侵入性光学相干层析成像(OCT)，光学微弹性成像能够在三维试件中以~10 μm的分辨率确定弹性性质。剪切波速测量可以用来量化弹性模量值。然而，在目前的方法中，横波是在表面波的干扰下在地表附近测量的。在这项研究中，我们发展了声辐射力(ARF)正交激发光学相干弹性成像(ARFOE-OCE)来可视化三维剪切波。该方法利用垂直于OCT波束的声学作用力在内部试件中激发横波，并利用多普勒方差法对横波的传播进行三维可视化。测得的横波传播与有限元模拟结果吻合较好。正交声激励使这种方法可以测量更深的试件的剪切模数，从而将弹性测量范围扩展到OCT成像深度之外。结果表明，ARFOE-OCE系统具有无创确定三维弹性图的能力。
Elastography provides a powerful tool for histopathological identification and clinical diagnosis based on information from tissue stiffness. Benefiting from high resolution, three-dimensional (3D), and noninvasive optical coherence tomography (OCT), optical micro-elastography has the ability to determine elastic properties with a resolution of ~10 μm in a 3D specimen. The shear wave velocity measurement can be used to quantify the elastic modulus. However, in current methods, shear waves are measured near the surface with an interference of surface waves. In this study, we developed acoustic radiation force (ARF) orthogonal excitation optical coherence elastography (ARFOE-OCE) to visualize shear waves in 3D. This method uses acoustic force perpendicular to the OCT beam to excite shear waves in internal specimens and uses Doppler variance method to visualize shear wave propagation in 3D. The measured propagation of shear waves agrees well with the simulation results obtained from finite element analysis (FEA). Orthogonal acoustic excitation allows this method to measure the shear modulus in a deeper specimen which extends the elasticity measurement range beyond the OCT imaging depth. The results show that the ARFOE-OCE system has the ability to noninvasively determine the 3D elastic map.
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使用相位敏感的光学相干断层扫描来可视化超声诱导的剪切波传播，以进行动态弹性摄影。
影响因子：
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