Prenatal exposure to polychlorinated biphenyls: a neuropsychologic analysis.
Prenatal exposure to polychlorinated biphenyls: a neuropsychologic analysis.
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DOI：
10.1289/ehp.11294
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发表时间：
2009-01
影响因子：
10.4
通讯作者：
Bastien, Celyne H.
中科院分区：
文献类型：
--
作者：
Boucher, Olivier;Muckle, Gina;Bastien, Celyne H.
关键词：
大量文献记录了产前暴露于多氯联苯（PCBs）对儿童认知发育的影响。尽管如此，还没有发表综合性的综合报告来确定特别受影响的认知功能。我们的目的是回顾这篇文献，试图确定与产前PCB暴露相关的认知特征。通过检索PubMed数据库中2008年6月之前发表的文章来确定研究。我们回顾了来自9个前瞻性纵向出生队列的不同认知方面的数据。在选定的研究中报告的产前PCB暴露和认知任务的性能指标之间的关联进行了总结和分类为一般认知能力，语言或视觉空间技能，记忆，注意力和执行功能。在所有研究中观察到的最一致的影响是与产前多氯联苯暴露增加有关的执行功能受损。大多数研究也报告了对处理速度、语言能力和视觉识别记忆的负面影响。在不同的队列研究中，接触来自不同的来源，这些研究的结果趋于一致，因此，与另一种相关污染物的共同接触不太可能是所观察到的影响的原因。产前接触多氯联苯似乎与一个相对具体的认知功能障碍有关。未能评估具体受损的功能可能解释了一些研究中发现的影响的缺乏。我们的研究结果对未来研究中认知评估方法的选择具有启示意义。
A large body of literature documents the effects of prenatal exposure to polychlorinated biphenyls (PCBs) on cognitive development of children. Despite this fact, no integrative synthesis has been published yet to identify the cognitive functions that are particularly affected. Our aim is to review this literature in an attempt to identify the cognitive profile associated with prenatal PCB exposure. Studies were identified by searching the PubMed database for articles published before June 2008. We reviewed data from nine prospective longitudinal birth cohorts for different aspects of cognition. Associations between indicators of prenatal PCB exposure and performance on cognitive tasks reported in the selected studies are summarized and classified as general cognitive abilities, verbal or visual–spatial skills, memory, attention, and executive functions. The most consistent effects observed across studies are impaired executive functioning related to increased prenatal PCB exposure. Negative effects on processing speed, verbal abilities, and visual recognition memory are also reported by most studies. Converging results from different cohort studies in which exposure arises from different sources make it unlikely that co-exposure with another associated contaminant is responsible for the observed effects. Prenatal PCB exposure appears to be related to a relatively specific cognitive profile of impairments. Failure to assess functions that are specifically impaired may explain the absence of effects found in some studies. Our findings have implications in the selection of cognitive assessment methods in future studies.
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影响因子：
5
作者：
Daniels, JL;Longnecker, MP;Needham, LL
通讯作者：
Needham, LL
DOI：
10.2478/v10004-007-0025-3
发表时间：
2007-09-01
期刊：
Arhiv za Higijenu Rada i Toksikologiju
影响因子：
--
作者：
Costa, Lucio G.
通讯作者：
Costa, Lucio G.
影响因子：
2.9
作者：
Després, C;Beuter, A;Muckle, G
通讯作者：
Muckle, G
影响因子：
5.1
作者：
GLADEN, BC;ROGAN, WJ;TULLY, M
通讯作者：
TULLY, M
影响因子：
1.5
作者：
Canfield, RL;Gendle, MH;Cory-Slechta, DA
通讯作者：
Cory-Slechta, DA