The role of sex in the association between cannabis use and working memory-related brain activity.
The role of sex in the association between cannabis use and working memory-related brain activity.
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DOI：
10.1002/jnr.25041
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发表时间：
2022-06
影响因子：
4.2
通讯作者：
Cousijn, Janna
中科院分区：
文献类型：
--
作者：
Kroon, Emese;Kuhns, Lauren N.;Kaag, Anne Marije;Filbey, Francesca;Cousijn, Janna
虽然男性和女性使用大麻的方式不同，但关于大麻对大脑和认知控制的影响的性别差异的研究在很大程度上缺乏。工作记忆（WM）是认知控制的一个组成部分，被认为与成瘾的发展和维持有关。在这项研究中，我们在一个大样本中评估了大麻使用与WM（负荷）相关的大脑活动之间的关系，使我们能够评估这种关系中的性别影响。在N - back WM任务中，记录了104名经常吸食大麻的人（63%为男性）和85名对照者（53%为男性）的大脑活动。行为结果显示，WM负荷与组间在准确性和反应时间上存在显著的交互作用，大麻使用者表现出相对较大的WM负荷下降。与对照组相比，大麻使用者在较高的WM负荷下，楔前叶和后扣带皮层的WM（负荷）相关活动的减少相对较小。这种WM（负荷）相关的活动与表现、大麻使用和相关问题无关。一项探索性分析显示，与女性相比，男性额上回的WM相关活动更高。虽然大麻使用者在默认模式网络的中心节点显示出更高的WM（负荷）相关活动，但这并不是直接归因于高认知负荷下组特定表现的恶化。需要进一步的研究来评估观察到的群体差异是否随着认知负荷的增加而增加，群体差异如何与大麻使用的测量相关联，以及性别如何影响这些群体差异。与对照组相比，大麻使用者在增加工作记忆负荷时表现出相对较大的表现下降，而在高工作记忆负荷时，楔前叶和后扣带皮层的工作记忆相关活动相对较小的下降。在WM和WM负荷相关的活动或表现中，一般或大麻使用者没有出现性别差异。
Although cannabis use patterns differ between men and women, studies on sex differences on the effects of cannabis on the brain and cognitive control are largely lacking. Working memory (WM) is a component of cognitive control believed to be involved in the development and maintenance of addiction. In this study, we evaluated the association between cannabis use and WM (load) related brain activity in a large sample, enabling us to assess sex effects in this association. The brain activity of 104 frequent cannabis users (63% men) and 85 controls (53% men) was recorded during an N‐back WM task. Behavioral results showed a significant interaction between WM load and group for both accuracy and reaction time, with cannabis users showing a relatively larger decrease in performance with increasing WM load. Cannabis users compared to controls showed a relatively smaller reduction in WM (load) related activity in the precuneus and posterior cingulate cortex at higher WM load. This WM (load) related activity was not associated with performance nor cannabis use and related problems. An exploratory analysis showed higher WM‐related activity in the superior frontal gyrus in men compared to women. While cannabis users showed higher WM (load) related activity in central nodes of the default mode network, this was not directly attributable to group specific worsening of performance under higher cognitive load. Further research is necessary to assess whether observed group differences increase with higher cognitive load, how group differences relate to measures of cannabis use, and how sex affects these group differences. Compared to controls, cannabis users show a relatively larger decrease in performance with increasing working memory (WM) load and a relatively smaller reduction in WM related activity in the precuneus and posterior cingulate cortex at higher WM load. No sex differences emerged generally or in cannabis users in WM and WM load related activity or performance.
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DOI：
10.1007/s11469-020-00226-y
发表时间：
2020-01-29
影响因子：
8
作者：
Hatchard, Taylor;Byron-Alhassan, Aziza;Smith, Andra
通讯作者：
Smith, Andra
DOI：
10.1016/j.pbb.2016.01.007
发表时间：
2017-01
期刊：
Pharmacology, biochemistry, and behavior
影响因子：
--
作者：
Fogel JS;Kelly TH;Westgate PM;Lile JA
通讯作者：
Lile JA
影响因子：
5.5
作者：
Crean RD;Crane NA;Mason BJ
通讯作者：
Mason BJ
DOI：
10.1016/j.pbb.2017.09.009
发表时间：
2018-01
期刊：
Pharmacology, biochemistry, and behavior
影响因子：
--
作者：
Bickel WK;Mellis AM;Snider SE;Athamneh LN;Stein JS;Pope DA
通讯作者：
Pope DA
影响因子：
4.3
作者：
Calakos, Katina C;Bhatt, Shivani;Cosgrove, Kelly P
通讯作者：
Cosgrove, Kelly P