Effect of wall type, delayed mortality and mosquito age on the residual efficacy of a clothianidin-based indoor residual spray formulation (SumiShield™ 50WG) in southern Mozambique
Effect of wall type, delayed mortality and mosquito age on the residual efficacy of a clothianidin-based indoor residual spray formulation (SumiShield™ 50WG) in southern Mozambique
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莫桑比克南部墙壁类型、延迟死亡率和蚊龄对基于噻虫胺的室内滞留喷雾制剂 (SumiShield™ 50WG) 残留效力的影响
DOI：
10.1101/2021.03.03.433723
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Marti-Soler H
中科院分区：
文献类型：
--
作者：
Marti-Soler H
室内滞留喷洒（IRS）是莫桑比克除分发经杀虫剂处理的蚊帐外的主要疟疾病媒控制战略之一。作为国家杀虫剂耐药性管理战略的一部分，莫桑比克于2018年推出了第三代IRS产品SumiShield™50WG。在2018-2019年疟疾季节，在莫桑比克南部评估了其剩余效力。使用一种敏感的阿拉伯按蚊菌株，使用世界卫生组织标准锥体生物测定试验，在三个不同高度，在水泥和泥抹墙两种不同的墙面上评估残留效力。2 ~ 5日龄和13 ~ 26日龄两组雌蚊暴露30 min后，分别于暴露后24h、48h、72h、96h和120h观察死亡情况，评估（延迟）死亡情况。使用贝叶斯模型估计致死时间（LT） 90、LT50和LT10。无论壁面类型如何，幼蚊和老蚊接触后24小时的死亡率始终低于世卫组织目前有效IRS阈值80%。考虑延迟死亡，残留效力（蚊子死亡率等于或大于80%）范围为1.5 ~≥12.5个月，其持续时间取决于暴露后的死亡时间、墙壁类型和蚊子年龄。观察暴露后72h的死亡率，根据墙的类型和蚊子的年龄，剩余效力在6.5至9.5个月之间。lt50和LT10(即：年龄较大的蚊子的LT50和LT10值（除暴露后48和72h的LT10值外）持续较高，分别为0.9 ~ 5.8个月和0.2 ~ 7.8个月。目前的研究强调有必要评估目前建议的暴露后24小时之后蚊子的死亡率。如果不这样做，可能会导致低估室内滞留剂产品的残留功效，因为延迟死亡将导致蚊虫媒介种群进一步减少，并可能对疾病传播产生负面影响。监测相关墙面的残留功效，包括对疟疾传播负有最终责任的老蚊子，以及评估延迟死亡，对于提供准确和可操作的数据以指导病媒控制规划至关重要。
Indoor residual spraying (IRS) is one of the main malaria vector control strategies in Mozambique alongside the distribution of insecticide treated nets. As part of the national insecticide resistance management strategy, Mozambique introduced SumiShield™50WG, a third generation IRS product, in 2018. Its residual efficacy was assessed in southern Mozambique during the 2018–2019 malaria season. Using a susceptibleAnopheles arabiensisstrain, residual efficacy was assessed on two different wall surfaces, cement and mud-plastered walls, using standard WHO (World Health Organization) cone bioassay tests at three different heights. Female mosquitoes of two age groups (2–5 and 13–26 day old) were exposed for 30 minutes, after which mortality was observed 24h, 48h, 72h, and 96h and 120h post-exposure to assess (delayed) mortality. Lethal times (LT) 90, LT50 and LT10 were estimated using Bayesian models. Mortality 24h post exposure was consistently below 80%, the current WHO threshold value for effective IRS, in both young and old mosquitoes, regardless of wall surface type. Considering delayed mortality, residual efficacies (mosquito mortality equal or greater than 80%) ranged from 1.5 to ≥12.5 months, with the duration depending on mortality time post exposure, wall type and mosquito age. Looking at mortality 72h after exposure, residual efficacy was between 6.5 and 9.5 months, depending on wall type and mosquito age. The LT50and LT10(i.e. 90% of the mosquitoes survive exposure to the insecticides) values were consistently higher for older mosquitoes (except for LT10 values for 48h and 72h post-exposure mortality) and ranged from 0.9 to 5.8 months and 0.2 to 7.8 months for LT50 and LT10, respectively. The present study highlights the need for assessing mosquito mortality beyond the currently recommended 24h post exposure. Failure to do so may lead to underestimation of the residual efficacy of IRS products, as delayed mortality will lead to a further reduction in mosquito vector populations and potentially negatively impact disease transmission. Monitoring residual efficacy on relevant wall surfaces, including old mosquitoes that are ultimately responsible for malaria transmission, and assessing delayed mortalities are critical to provide accurate and actionable data to guide vector control programmes.
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影响因子：
3
作者：
Arroz JAH;Candrinho B;Pedro S;Mathe G;da Silva M;Tsabete S;Ismael L;Juleca I;Chande M;Bambo F;Munguande O;Julane S;Mussambala F;Alfai E;Muianga O;Matsimbe H;Varela P;Latif C;Mendis C;Lopez M;Karapetyan G;Erskine M
通讯作者：
Erskine M
影响因子：
3
作者：
Mbepera S;Nkwengulila G;Peter R;Mausa EA;Mahande AM;Coetzee M;Kweka EJ
通讯作者：
Kweka EJ
DOI：
10.1016/s0140-6736(15)00417-1
发表时间：
2016-04-23
期刊：
Lancet (London, England)
影响因子：
--
作者：
Hemingway J;Ranson H;Magill A;Kolaczinski J;Fornadel C;Gimnig J;Coetzee M;Simard F;Roch DK;Hinzoumbe CK;Pickett J;Schellenberg D;Gething P;Hoppé M;Hamon N
通讯作者：
Hamon N
影响因子：
3.2
作者：
Agossa FR;Padonou GG;Koukpo CZ;Zola-Sahossi J;Azondekon R;Akuoko OK;Ahoga J;N'dombidje B;Akinro B;Fassinou AJYH;Sezonlin M;Akogbeto MC
通讯作者：
Akogbeto MC
影响因子：
3.2
作者：
Thawer NG;Ngondi JM;Mugalura FE;Emmanuel I;Mwalimu CD;Morou E;Vontas J;Protopopoff N;Rowland M;Mutagahywa J;Lalji S;Molteni F;Ramsan MM;Willilo R;Wright A;Kafuko JM;Ndong I;Reithinger R;Magesa SM
通讯作者：
Magesa SM