Long wavelength light reduces the negative consequences of dim light at night.
Long wavelength light reduces the negative consequences of dim light at night.
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长波长光减少了夜间昏暗光的负面后果。
DOI：
10.1016/j.nbd.2022.105944
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发表时间：
2023-01
影响因子：
6.1
通讯作者：
Colwell, Christopher S.
中科院分区：
文献类型：
--
作者：
Wang, Huei-Bin;Zhou, David;Luk, Shu Hon Christopher;Cha, Hye In;Mac, Amanda;Chae, Rim;Matynia, Anna;Harrison, Ben;Afshari, Sina;Block, Gene D.;Ghiani, Cristina A.;Colwell, Christopher S.
许多自闭症谱系障碍（ASD）患者在睡眠/觉醒周期中表现出干扰，他们可能特别容易受到昼夜节律干扰的影响。我们之前已经证明，在夜间暴露于昏暗的灯光（DLaN）2周会破坏昼夜节律，增加重复行为，并减少接触相关蛋白样2敲除（Cntnap 2 KO）小鼠的社会互动。DLaN的有害作用可以由表达对蓝光（480 nm）最敏感的色素黑视蛋白的固有光敏视网膜神经节细胞（ipRGC）介导。在这项研究中，发光二极管阵列的使用使我们能够改变DLaN的光谱特性，同时将照明强度保持在10 lx。首先，我们证实了短波长丰富的照明产生强烈的急性抑制自发活动（掩蔽），强大的光诱导的相移，并在野生型（WT）小鼠的视交叉上核cFos表达，而长波长丰富的照明引起弱得多的反应。缺乏表达黑视蛋白的ipRGC的Opn 4DTA小鼠对DLaN效应具有抗性。重要的是，将DLaN刺激转移到更长的波长减轻了对Cntnap 2 KO以及WT小鼠中的活动节律和“自闭症”行为（即相互社会互动，重复梳理）的负面影响。短波长而非长波长富集的DLaN触发了基底外侧杏仁核（BLA）以及缰核周围区域中的cFos表达，这提高了这些细胞群可能介导效应的可能性。总的来说，我们的研究结果与建议一致，即应考虑夜间光的光谱特性，以优化神经典型人群和弱势人群的健康。
Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycles, and they may be particularly vulnerable to the impact of circadian disruptors. We have previously shown that a 2-weeks exposure to dim light at night (DLaN) disrupts diurnal rhythms, increases repetitive behaviors and reduces social interactions in contactin-associated protein-like 2 knock out (Cntnap2 KO) mice. The deleterious effects of DLaN may be mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin, which is maximally sensitive to blue light (480 nm). In this study, the usage of a light-emitting diode array enabled us to shift the spectral properties of the DLaN while keeping the intensity of the illumination at 10 lx. First, we confirmed that the short-wavelength enriched lighting produced strong acute suppression of locomotor activity (masking), robust light-induced phase shifts, and cFos expression in the suprachiasmatic nucleus in wild-type (WT) mice, while the long-wavelength enriched lighting evoked much weaker responses. Opn4DTA mice, lacking the melanopsin expressing ipRGCs, were resistant to DLaN effects. Importantly, shifting the DLaN stimulus to longer wavelengths mitigated the negative impact on the activity rhythms and ‘autistic’ behaviors (i.e. reciprocal social interactions, repetitive grooming) in the Cntnap2 KO as well as in WT mice. The short-, but not the long-wavelength enriched, DLaN triggered cFos expression in in the basolateral amygdala (BLA) as well as in the peri-habenula region raising that possibility that these cell populations may mediate the effects. Broadly, our findings are consistent with the recommendation that spectral properties of light at night should be considered to optimize health in neurotypical as well as vulnerable populations.
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影响因子：
25
作者：
Altimus, Cara M.;Gueler, Ali D.;Alam, Nazia M.;Arman, A. Cyrus;Prusky, Glen T.;Sampath, Alapakkam P.;Hattar, Samer
通讯作者：
Hattar, Samer
影响因子：
64.8
作者：
Gueler, Ali D.;Ecker, Jennifer L.;Hattar, Samer
通讯作者：
Hattar, Samer
影响因子：
4.7
作者：
Dong HY;Wang B;Li HH;Yue XJ;Jia FY
通讯作者：
Jia FY
影响因子：
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作者：
Chew, Kylie S.;Renna, Jordan M.;Hattar, Samer
通讯作者：
Hattar, Samer
影响因子：
3.3
作者：
Bedrosian, Tracy A.;Fonken, Laura K.;Nelson, Randy J.
通讯作者：
Nelson, Randy J.