Phage WO of Wolbachia: lambda of the endosymbiont world.

Phage WO of Wolbachia: lambda of the endosymbiont world.
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DOI:
10.1016/j.tim.2009.12.011
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发表时间:
2010-04
影响因子:
15.9
通讯作者:
Bordenstein SR
Bordenstein SR
中科院分区:
生物学1区
文献类型:
--
作者:
Kent BN;Bordenstein SR

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沃尔巴克氏体(Wolbachia)是一种广泛分布的节肢动物和线虫内共生体,其基因组中发现了异常高水平的移动元件,这表明这种细菌可能是评估特殊细菌中移动DNA的进化和功能的绝佳模型。在这里,我们讨论了对沃尔巴克氏体温带噬菌体 WO 的研究如何揭示了意想不到的基因组通量水平,并挑战了先前关于专性细胞内细菌克隆性的观点。我们还讨论了这种噬菌体在沃尔巴克氏体-节肢动物共生中可能发挥的作用,并推断如何将这项研究转化为对抗节肢动物传播的人类疾病。我们期望这种温带噬菌体将成为了解专性细胞内细菌中噬菌体遗传学、进化和生态学的卓越模型系统。从这个意义上说,噬菌体 WO 可以比作内共生世界的噬菌体 λ。
The discovery of an extraordinarily high level of mobile elements in the genome of Wolbachia, a widespread arthropod and nematode endosymbiont, suggests that this bacterium could be an excellent model for assessing the evolution and function of mobile DNA in specialized bacteria. Here, we discuss how studies on the temperate bacteriophage WO of Wolbachia have revealed unexpected levels of genomic flux and are challenging previously held views about the clonality of obligate intracellular bacteria. We also discuss the roles that this phage might play in the Wolbachia-arthropod symbiosis, and infer how this research can be translated to combating human diseases vectored by arthropods. We expect that this temperate phage will be a preeminent model system to understand phage genetics, evolution, and ecology in obligate intracellular bacteria. In this sense, phage WO might be likened to phage λ of the endosymbiont world.
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