Behaviourally inhibited temperament and female sex, two vulnerability factors for anxiety disorders, facilitate conditioned avoidance (also) in humans.
Behaviourally inhibited temperament and female sex, two vulnerability factors for anxiety disorders, facilitate conditioned avoidance (also) in humans.
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DOI：
10.1016/j.beproc.2014.01.003
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发表时间：
2014-03
影响因子：
1.3
通讯作者：
Myers CE
中科院分区：
文献类型：
--
作者：
Sheynin J;Beck KD;Pang KC;Servatius RJ;Shikari S;Ostovich J;Myers CE
获得和维持回避行为是所有人类焦虑症的关键特征。动物模型在理解焦虑易感性如何转化为回避学习方面很有用。例如，行为受抑的气质和女性性别是临床焦虑的两个脆弱因素，与啮齿类动物获得更快的回避反应有关。然而，到目前为止，这种经验数据到人类群体的转换一直是有限的，因为动物回避范式的许多特征在人类研究中通常没有捕捉到。在这里，我们使用了一项基于计算机的任务，该任务捕捉了啮齿动物逃避-回避学习范式的许多特征，我们调查了气质受抑制和/或女性性别的人是否会更快地学习回避，如果是的话，这种促进是否会采取相同的形式。结果表明，与大鼠一样，这两个易感因素都与人类回避行为的易得性获得有关。具体地说，受抑制的气质与较高的回避反应率有关，而女性与较长的回避持续时间有关。这些发现加强了动物回避工作和人类焦虑脆弱性之间的直接联系，进一步激励了对动物模型的研究，同时也为直接进行人类测试提供了一个简单的试验台。
Acquisition and maintenance of avoidance behaviour is a key feature of all human anxiety disorders. Animal models have been useful in understanding how anxiety vulnerability could translate into avoidance learning. For example, behaviourally-inhibited temperament and female sex, two vulnerability factors for clinical anxiety, are associated with faster acquisition of avoidance responses in rodents. However, to date, the translation of such empirical data to human populations has been limited since many features of animal avoidance paradigms are not typically captured in human research. Here, using a computer-based task that captures many features of rodent escape-avoidance learning paradigms, we investigated whether avoidance learning would be faster in humans with inhibited temperament and/or female sex and, if so, whether this facilitation would take the same form. Results showed that, as in rats, both vulnerability factors were associated with facilitated acquisition of avoidance behaviour in humans. Specifically, inhibited temperament was specifically associated with higher rate of avoidance responding, while female sex was associated with longer avoidance duration. These findings strengthen the direct link between animal avoidance work and human anxiety vulnerability, further motivating the study of animal models while also providing a simple testbed for a direct human testing.
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DOI：
10.1097/chi.0b013e3181ae09df
发表时间：
2009-09
影响因子：
13.3
作者：
Chronis-Tuscano A;Degnan KA;Pine DS;Perez-Edgar K;Henderson HA;Diaz Y;Raggi VL;Fox NA
通讯作者：
Fox NA
影响因子：
4.1
作者：
Dymond, Simon;Schlund, Michael W.;Davies, Cara
通讯作者：
Davies, Cara
影响因子：
2.7
作者：
Aupperle, Robin L.;Sullivan, Sarah;Melrose, Andrew J.;Paulus, Martin P.;Stein, Murray B.
通讯作者：
Stein, Murray B.
DOI：
10.1007/bf03392173
发表时间：
2009-03-01
期刊：
BEHAVIOR ANALYST
影响因子：
--
作者：
Dymond, Simon;Roche, Bryan
通讯作者：
Roche, Bryan
影响因子：
14.5
作者：
Bodi, Nikoletta;Keri, Szabolcs;Gluck, Mark A.
通讯作者：
Gluck, Mark A.