Seroepidemiology of Klebsiella pneumoniae colonizing the intestinal tract of healthy Chinese and overseas Chinese adults in Asian countries.
Seroepidemiology of Klebsiella pneumoniae colonizing the intestinal tract of healthy Chinese and overseas Chinese adults in Asian countries.
复制标题
DOI：
10.1186/1471-2180-12-13
复制
发表时间：
2012-01-19
期刊：
影响因子：
4.2
通讯作者：
Fung CP
中科院分区：
文献类型：
--
作者：
Lin YT;Siu LK;Lin JC;Chen TL;Tseng CP;Yeh KM;Chang FY;Fung CP
肺炎克雷伯菌的荚膜血清型K1和K2被认为是导致肝脓肿的主要毒力决定因素。肠道是钾的主要储存库之一。肺炎克雷伯氏菌，流行病学研究表明，大多数K。肺炎感染之前是胃肠道的定殖。在分离株分子分型的基础上，提出了肝脓肿粪-口传播的可能性。K.来自健康个体的粪便样品中存在肺炎链球菌之前尚未报道。本研究对克雷伯氏菌进行了血清流行病学调查。从亚洲国家健康中国人肠道中分离的pneumoniae菌株。从2004年8月至2010年8月，从中国台湾、日本、中国香港、泰国、马来西亚、新加坡和越南的健康成年中国居民中收集粪便标本进行分析。K1/K2血清型占总克雷伯菌的9.8%。在所有国家从粪便中分离出肺炎分离株。除泰国和越南外，K1/K2分离株的流行率在各国之间没有显著差异。K.肺炎分离株。脉冲场凝胶电泳结果显示K1血清型分离株无主要克隆群。结果表明，中国民族本身可能是K1/K2 K血清型肠道定植的主要易感因素。肺炎分离株。流行的K1/K2血清型可能与K.肺炎肝脓肿在亚洲国家。
Capsular serotypes K1 and K2 of Klebsiella pneumoniae are thought to the major virulence determinants responsible for liver abscess. The intestine is one of the major reservoirs of K. pneumoniae, and epidemiological studies have suggested that the majority of K. pneumoniae infections are preceded by colonization of the gastrointestinal tract. The possibility of fecal-oral transmission in liver abscess has been raised on the basis of molecular typing of isolates. Data on the serotype distribution of K. pneumoniae in stool samples from healthy individuals has not been previously reported. This study investigated the seroepidemiology of K. pneumoniae isolates from the intestinal tract of healthy Chinese in Asian countries. Stool specimens from healthy adult Chinese residents of Taiwan, Japan, Hong Kong, China, Thailand, Malaysia, Singapore, and Vietnam were collected from August 2004 to August 2010 for analysis. Serotypes K1/K2 accounted for 9.8% of all K. pneumoniae isolates from stools in all countries. There was no significant difference in the prevalence of K1/K2 isolates among the countries excluding Thailand and Vietnam. The antimicrobial susceptibility pattern was nearly the same in K. pneumoniae isolates. The result of pulsed-field gel electrophoresis revealed no major clonal cluster of serotype K1 isolates. The result showed that Chinese ethnicity itself might be a major factor predisposing to intestinal colonization by serotype K1/K2 K. pneumoniae isolates. The prevalent serotype K1/K2 isolates may partially correspond to the prevalence of K. pneumoniae liver abscess in Asian countries.
登录
查看更多内容
影响因子：
28.2
作者：
Chung, D. R.;Lee, S. S.;Park, C. K.
通讯作者：
Park, C. K.
影响因子：
11.8
作者：
Wang, JH;Liu, YC;Lin, HH
通讯作者：
Lin, HH
影响因子：
9.4
作者：
CRYZ, SJ;MORTIMER, PM;GERMANIER, R
通讯作者：
GERMANIER, R
影响因子：
9.4
作者：
Yeh, Kuo-Ming;Kurup, A.;Koh, Tse-Hsien
通讯作者：
Koh, Tse-Hsien
DOI：
10.1016/s0732-8893(00)00157-7
发表时间：
2000-08-01
影响因子：
2.9
作者：
Chang, SC;Fang, CT;Luh, KT
通讯作者：
Luh, KT