Working memory-related changes in functional connectivity persist beyond task disengagement.
Working memory-related changes in functional connectivity persist beyond task disengagement.
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DOI：
10.1002/hbm.22230
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发表时间：
2014-03
影响因子：
4.8
通讯作者：
Vaidya, Chandan J.
中科院分区：
文献类型：
--
作者：
Gordon, Evan M.;Breeden, Andrew L.;Bean, Stephanie E.;Vaidya, Chandan J.
我们研究了在工作记忆表现过程中，功能网络中的连接性改变是否会在该表现的结论之后持续到随后的静息状态。我们进行了功能性磁共振成像（fMRI）在50名年轻人在最初的休息状态，随后的N-back工作记忆任务和随后的休息状态，以检查功能连接的变化内和之间的默认模式网络（DMN）和任务积极网络（TPN）在三个国家。我们发现，在N-back任务期间观察到的连接变化持续到TPN内和DMN与TPN之间的后续静息状态，但不在DMN内。此外，工作记忆的性能和TPN连接强度的速度在N-back任务预测连接强度在随后的休息状态。最后，在N-back任务之前和期间测量的DMN连接预测自我报告的注意力不集中的个体差异，但在任务后的休息状态下没有发现这种关联。总之，这些发现对大脑如何在努力认知后恢复的模型以及使用休息和任务扫描的实验设计具有重要意义。
We examined whether altered connectivity in functional networks during working memory performance persists following conclusion of that performance, into a subsequent resting state. We conducted functional magnetic resonance imaging (fMRI) in 50 young adults during an initial resting state, followed by an N-back working memory task and a subsequent resting state, in order to examine changes in functional connectivity within and between the default-mode network (DMN) and the task-positive network (TPN) across the three states. We found that alterations in connectivity observed during the N-back task persisted into the subsequent resting state within the TPN and between the DMN and TPN, but not within the DMN. Further, speed of working memory performance and TPN connectivity strength during the N-back task predicted connectivity strength in the subsequent resting state. Finally, DMN connectivity measured before and during the N-back task predicted individual differences in self-reported inattentiveness, but this association was not found during the post-task resting state. Together, these findings have important implications for models of how the brain recovers following effortful cognition, as well as for experimental designs using resting and task scans.
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影响因子：
11.3
作者：
Brown AB;Biederman J;Valera E;Makris N;Doyle A;Whitfield-Gabrieli S;Mick E;Spencer T;Faraone S;Seidman L
通讯作者：
Seidman L
DOI：
10.1016/j.cub.2009.04.028
发表时间：
2009-06-23
期刊：
Current biology : CB
影响因子：
--
作者：
Albert NB;Robertson EM;Miall RC
通讯作者：
Miall RC
影响因子：
3.7
作者：
Barnes A;Bullmore ET;Suckling J
通讯作者：
Suckling J
影响因子：
5.7
作者：
Fransson, Peter;Marrelec, Guillaume
通讯作者：
Marrelec, Guillaume
影响因子：
4.8
作者：
Jiang, TZ;He, Y;Weng, XC
通讯作者：
Weng, XC