Meta-analysis and systematic review of the literature characterizing auditory mismatch negativity in individuals with autism.
Meta-analysis and systematic review of the literature characterizing auditory mismatch negativity in individuals with autism.
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DOI：
10.1016/j.neubiorev.2018.01.008
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发表时间：
2018-04
影响因子：
8.2
通讯作者：
Tager-Flusberg H
中科院分区：
文献类型：
--
作者：
Schwartz S;Shinn-Cunningham B;Tager-Flusberg H
过去的一些研究已经使用失配负波（MMN）来识别自闭症谱系障碍（ASD）患者的听觉处理缺陷。我们的荟萃分析比较了ASD患者和典型发展对照（TD）患者的MMN反应。我们分析了22篇出版物中的67个实验，这些出版物采用了被动的、基于遗传学的MMN范式，参与者包括ASD和TD。大多数研究缺乏设计特征，这将导致MMN的准确描述。测量MMN振幅的实验之间的变异性较小时，仅限于研究，抵消刺激。与对照组和使用非言语声音的实验相比，ASD幼儿的MMN振幅降低。尽管如此，很少有研究包括青少年或那些语言智商低于平均水平的人。大多数研究的样本量都很小，汇总这些数据并没有显示出显著的组间差异。这一分析指出，需要研究专门针对未充分研究的ASD样本，使用精心设计的MMN实验。研究MMN的个体差异可能会进一步深入了解异质性ASD人群中的不同亚组。
A number of past studies have used mismatch negativity (MMN) to identify auditory processing deficits in individuals with autism spectrum disorder (ASD). Our meta-analysis compared MMN responses for individuals with ASD and typically developing controls (TD). We analyzed 67 experiments across 22 publications that employed passive, auditory-based MMN paradigms with ASD and TD participants. Most studies lacked design characteristics that would lead to an accurate description of the MMN. Variability between experiments measuring MMN amplitude was smaller when limited to studies that counterbalanced stimuli. Reduced MMN amplitude was found among young children with ASD compared to controls and in experiments that used nonspeech sounds. Still, few studies included adolescents or those with below-average verbal IQ. Most studies suffered from small sample sizes, and aggregating these data did not reveal significant group differences. This analysis points to a need for research focused specifically on understudied ASD samples using carefully designed MMN experiments. Study of individual differences in MMN may provide further insights into distinct subgroups within the heterogeneous ASD population.
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影响因子：
3.7
作者：
Bishop DV;Hardiman MJ
通讯作者：
Hardiman MJ
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
1.7
作者：
Cardy, JEO;Flagg, EJ;Roberts, TPL
通讯作者：
Roberts, TPL
影响因子：
2.5
作者：
Andersson, Stein;Posserud, Maj-Britt;Lundervold, Astri J.
通讯作者：
Lundervold, Astri J.
影响因子：
2.6
作者：
Bonnel, Anna;McAdams, Stephen;Mottron, Laurent
通讯作者：
Mottron, Laurent