Integrity of Amygdala Subregion-Based Functional Networks and Emotional Lability in Drug-Naïve Boys With ADHD
Integrity of Amygdala Subregion-Based Functional Networks and Emotional Lability in Drug-Naïve Boys With ADHD
复制标题
患有多动症的未接触过药物的男孩中基于杏仁核亚区域的功能网络的完整性和情绪不稳定性
DOI：
10.1177/1087054716661419
复制
发表时间：
2020-10
影响因子：
3
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Yu X;Liu L;Chen W;Cao QJ;Zepf FD;Ji G;Wu Z;An L;Wang P;Qian Q;Zang Y;Sun L;Wang Y
目的：本研究评估了ADHD患者杏仁核亚区（基底外侧[BLA]，中央内侧[CMA]和浅杏仁核[SFA]）的功能网络及其与情绪不稳定（EL）症状的关系。方法：在35名药物初治ADHD男孩和30名年龄匹配的健康对照（HC）中评估了杏仁核亚区的静息状态功能连接（RSFC）及其与EL评分的相关性。结果如下：与HC相比，ADHD患者杏仁核各亚区的RSFC改变不同：BLA与丘脑和蚓部的RSFC改变; CMA与上级颞回/极、小脑、楔前叶和小脑的RSFC异常; SFA与背侧额顶皮质的RSFC降低。在ADHD中，较高的EL分数与背外侧前额叶皮层和顶叶下部的SFA负RSFC减少相关。结论：杏仁核亚区网络的弥漫性改变与ADHD相关，而较弱的SFA-额顶叶网络可能参与了假设的自上而下的情绪调节。
Objective: This study evaluated the functional networks of amygdala subregions (basolateral [BLA], centromedial [CMA], and superficial amygdala [SFA]) in ADHD and their association with emotional lability (EL) symptoms. Method: Resting-state functional connectivity (RSFC) of amygdala subregions and their correlations with EL scores were evaluated in 35 drug-naïve boys with ADHD and 30 age-matched healthy controls (HC). Results: Compared with HC, altered RSFC were detected differently for each amygdala subregion in ADHD: altered RSFC of BLA with the thalamus and vermis; aberrant RSFC of CMA with the superior temporal gyrus/pole and insula, precuneus and cerebellum; reduced RSFC of SFA with dorsal frontoparietal cortices. Within ADHD, higher EL scores were associated with reduced negative RSFC of SFA with the dorsolateral prefrontal cortex and inferior parietal lobe. Conclusion: Diffuse alterations of amygdala subregion-based networks are associated with ADHD, and the weaker SFA–frontoparietal networks might be involved in the hypothesized top–down effortful regulation of emotion.
登录
查看更多内容
杏仁核功能连通性的改变反映了早期气质。
影响因子：
2.6
作者：
Roy, Amy Krain;Benson, Brenda E.;Degnan, Kathryn A.;Perez-Edgar, Koraly;Pine, Daniel S.;Fox, Nathan A.;Ernst, Monique
通讯作者：
Ernst, Monique
冲动的个体差异预测磁共振成像期间的头部运动
影响因子：
3.7
作者：
Kong XZ;Zhen Z;Li X;Lu HH;Wang R;Liu L;He Y;Zang Y;Liu J
通讯作者：
Liu J
影响因子：
3.7
作者：
Song XW;Dong ZY;Long XY;Li SF;Zuo XN;Zhu CZ;He Y;Yan CG;Zang YF
通讯作者：
Zang YF
影响因子：
1.7
作者：
Bailey, Teresa;Joyce, Arthur
通讯作者：
Joyce, Arthur
影响因子：
5.7
作者：
Alarcón G;Cservenka A;Rudolph MD;Fair DA;Nagel BJ
通讯作者：
Nagel BJ