Influence of childhood adversity, approach motivation traits, and depression on individual differences in brain activation during reward anticipation.
Influence of childhood adversity, approach motivation traits, and depression on individual differences in brain activation during reward anticipation.
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DOI：
10.1016/j.biopsycho.2019.05.009
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发表时间：
2019-09
影响因子：
2.6
通讯作者：
Langenecker, Scott A.
中科院分区：
文献类型：
--
作者：
DelDonno, Sophie R.;Mickey, Brian J.;Pruitt, Patrick J.;Stange, Jonathan P.;Hsu, David T.;Weldon, Anne L.;Zubieta, Jon-Kar;Langenecker, Scott A.
奖赏预期障碍与严重抑郁障碍(MDD)有关，但在MDD患者中并不普遍观察到。奖赏预期不足也与童年逆境(CA)和接近/回避特征有关。本研究评估了CA的严重程度(由儿童创伤问卷测量)和接近/回避特征是否可以预测个体在血氧水平依赖(BOLD)反应中对超越MDD诊断的奖励预期的个体差异。研究对象为MDD患者(n=23)和健康对照组(n=27)。使用CTQ分数、特质接近/回避分数和诊断进行多元回归，以预测金钱激励延迟fMRI任务中奖励预期的激活。在所有组中，较高的特质奖赏反应性预示着海马体、扣带回和额叶内侧回的激活增加。CTQ得分越高，奖励网络激活程度越高。总体而言，CTQ和奖励反应性分数预测奖励预期激活的差异大于诊断。这些发现表明，临床医生在治疗MDD患者时，应该评估儿童逆境史和特质奖赏反应。
Reward anticipation dysfunction is associated with major depressive disorder (MDD), but is not universally observed in individuals with MDD. Reward anticipation deficits have also been linked to childhood adversity (CA) and approach/avoidance traits. The present study evaluated whether severity of CA (as measured by the Childhood Trauma Questionnaire) and approach/avoidance traits predict individual differences in blood oxygen level dependent (BOLD) response to reward anticipation beyond MDD diagnosis alone. Participants were individuals with MDD (n=23) and healthy controls (n=27). Multiple regression was conducted using CTQ scores, trait approach/avoidance scores, and diagnosis to predict activation during reward anticipation in a monetary incentive delay fMRI task. Across groups, higher trait reward responsiveness predicted increased activation in the hippocampus, cingulate cortex, and medial frontal gyrus. Greater CTQ scores predicted increased reward network activation. Overall, CTQ and reward responsiveness scores predicted more variance in reward anticipation activation than diagnosis. These findings suggest that clinicians should assess history of childhood adversity and trait reward responsiveness when treating individuals with MDD.
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早期逆境对年轻人奖励加工的影响：EEG-FMRI是由25年以上的一项前瞻性研究引起的。
影响因子：
3.7
作者：
Boecker R;Holz NE;Buchmann AF;Blomeyer D;Plichta MM;Wolf I;Baumeister S;Meyer-Lindenberg A;Banaschewski T;Brandeis D;Laucht M
通讯作者：
Laucht M
影响因子：
4.9
作者：
Dichter GS;Damiano CA;Allen JA
通讯作者：
Allen JA
影响因子：
--
作者：
Green, Jennifer Greif;McLaughlin, Katie A.;Berglund, Patricia A.;Gruber, Michael J.;Sampson, Nancy A.;Zaslavsky, Alan M.;Kessler, Ronald C.
通讯作者：
Kessler, Ronald C.
DOI：
10.1073/pnas.0910651106
发表时间：
2009-12-29
影响因子：
11.1
作者：
Heller, Aaron S.;Johnstone, Tom;Davidson, Richard J.
通讯作者：
Davidson, Richard J.
影响因子：
5.3
作者：
Beaver, John D.;Lawrence, Andrew D.;Calder, Andrew J.
通讯作者：
Calder, Andrew J.