Converging vulnerability factors for compulsive food and drug use.
Converging vulnerability factors for compulsive food and drug use.
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DOI：
10.1016/j.neuropharm.2021.108556
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发表时间：
2021-09-15
影响因子：
4.7
通讯作者：
Zorrilla EP
中科院分区：
文献类型：
--
作者：
Serafine KM;O'Dell LE;Zorrilla EP
高度可口的食物和滥用的物质具有交叉的神经生物学、代谢和行为效应，这些效应与理解对与食物有关的疾病的脆弱性有关（例如，肥胖症、暴食症）和药物（例如，物质使用障碍）滥用。在这里，我们回顾了动物模型，临床人群和流行病学证据在行为，遗传，病理生理和治疗领域的数据。结果表明，消费的美味食物和药物滥用的影响，反过来又调节代谢激素和代谢状态。高脂肪和/或高糖的可口食物可以引起大脑奖励和戒断回路的适应，类似于滥用物质。摄入或不摄入可口的食物会影响对滥用药物的行为敏感性，反之亦然。一个强大的文献表明，共同的基板和负强化的作用，负面影响，负面的紧迫感，冲动控制赤字，都非常可口的食物和物质的滥用。在与代谢和动机功能经典相关的分子中，已经确定了肥胖和酒精使用障碍共有的候选遗传风险位点。最后，某些药物在治疗肥胖、糖尿病、暴食相关的饮食失调和物质使用障碍方面可能具有重叠的治疗潜力。两者合计，数据是一致的假设，强迫性食物和物质的使用共享重叠，在神经生物学和代谢水平的相互作用的基板，并与喂养或物质的使用相关的动机行为可能构成彼此的脆弱性因素。
Highly palatable foods and substance of abuse have intersecting neurobiological, metabolic and behavioral effects relevant for understanding vulnerability to conditions related to food (e.g., obesity, binge eating disorder) and drug (e.g., substance use disorder) misuse. Here, we review data from animal models, clinical populations and epidemiological evidence in behavioral, genetic, pathophysiologic and therapeutic domains. Results suggest that consumption of highly palatable food and drugs of abuse both impact and conversely are regulated by metabolic hormones and metabolic status. Palatable foods high in fat and/or sugar can elicit adaptation in brain reward and withdrawal circuitry akin to substances of abuse. Intake of or withdrawal from palatable food can impact behavioral sensitivity to drugs of abuse and vice versa. A robust literature suggests common substrates and roles for negative reinforcement, negative affect, negative urgency, and impulse control deficits, with both highly palatable foods and substances of abuse. Candidate genetic risk loci shared by obesity and alcohol use disorders have been identified in molecules classically associated with both metabolic and motivational functions. Finally, certain drugs may have overlapping therapeutic potential to treat obesity, diabetes, binge-related eating disorders and substance use disorders. Taken together, data are consistent with the hypotheses that compulsive food and substance use share overlapping, interacting substrates at neurobiological and metabolic levels and that motivated behavior associated with feeding or substance use might constitute vulnerability factors for one another.
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影响因子：
5.4
作者：
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通讯作者：
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DOI：
10.4021/jocmr1159w
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