Associative cortex features in the first olfactory brain relay station.

Associative cortex features in the first olfactory brain relay station.
复制标题

DOI:
10.1016/j.neuron.2011.02.024
复制
发表时间:
2011-03-24
期刊:
影响因子:
16.2
通讯作者:
Restrepo D
Restrepo D
中科院分区:
医学1区
文献类型:
--
作者:
Doucette W;Gire DH;Whitesell J;Carmean V;Lucero MT;Restrepo D

文献摘要

参考文献

被引文献

相似文献

据推测,嗅球(OB)中的二尖瓣细胞(MC)的同步放电有助于嗅觉皮层(OC)中的信息绑定。在第一次调查中,我们发现了令人惊讶的结果,即同步放电传达了气味价值的信息(它是奖励吗?)而不是气味识别(什么是气味?)。我们观察到,当老鼠学会区分气味时,对奖励和非奖励气味的同步放电反应变得不同。此外,肾上腺素能阻滞降低了同步列车的气味发散的幅度,这表明MCs有助于通过肾上腺素能调制的同步放电的决策。因此,在嗅觉系统中,刺激奖励的信息在离感觉神经元一个突触远的MC中被发现。
Synchronized firing of mitral cells (MCs) in the olfactory bulb (OB) has been hypothesized to help bind information together in olfactory cortex (OC). In this first survey of synchronized firing by suspected MCs in awake-behaving vertebrates we find the surprising result that synchronized firing conveys information on odor value (is it rewarded?) rather than odor identity (what is the odor?). We observed that as mice learned to discriminate between odors synchronous firing responses to the rewarded and unrewarded odors became divergent. Further, adrenergic blockage decreases the magnitude of odor divergence of synchronous trains suggesting that MCs contribute to decision-making through adrenergic-modulated synchronized firing. Thus, in the olfactory system information on stimulus reward is found in MCs one synapse away from the sensory neuron.
DOI: 10.1016/j.neuron.2004.11.017
发表时间: 2004-12-02
期刊: NEURON
影响因子: 16.2
作者:
Abraham, NM;Spors, H;Schaefer, AT
通讯作者: Schaefer, AT
DOI: 10.1038/nn1292
发表时间: 2004-08-01
影响因子: 25
作者:
Friedrich, RW;Habermann, CJ;Laurent, G
通讯作者: Laurent, G
DOI: 10.1016/j.neuron.2005.12.026
发表时间: 2006-02-02
期刊: NEURON
影响因子: 16.2
作者:
Franks, KM;Isaacson, JS
通讯作者: Isaacson, JS
DOI: 10.1523/jneurosci.2747-10.2010
发表时间: 2010-10-20
期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子: --
作者:
Apicella A;Yuan Q;Scanziani M;Isaacson JS
通讯作者: Isaacson JS
DOI: 10.1038/nn.2319
发表时间: 2009-06
影响因子: 25
作者:
Gao, Yuan;Strowbridge, Ben W.
通讯作者: Strowbridge, Ben W.