Associative cortex features in the first olfactory brain relay station.
Associative cortex features in the first olfactory brain relay station.
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DOI:
10.1016/j.neuron.2011.02.024
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发表时间:
2011-03-24
期刊:
影响因子:
16.2
通讯作者:
Restrepo D
中科院分区:
文献类型:
--
作者:
Doucette W;Gire DH;Whitesell J;Carmean V;Lucero MT;Restrepo D
Synchronized firing of mitral cells (MCs) in the olfactory bulb (OB) has been hypothesized to help bind information together in olfactory cortex (OC). In this first survey of synchronized firing by suspected MCs in awake-behaving vertebrates we find the surprising result that synchronized firing conveys information on odor value (is it rewarded?) rather than odor identity (what is the odor?). We observed that as mice learned to discriminate between odors synchronous firing responses to the rewarded and unrewarded odors became divergent. Further, adrenergic blockage decreases the magnitude of odor divergence of synchronous trains suggesting that MCs contribute to decision-making through adrenergic-modulated synchronized firing. Thus, in the olfactory system information on stimulus reward is found in MCs one synapse away from the sensory neuron.
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影响因子:
16.2
作者:
Abraham, NM;Spors, H;Schaefer, AT
通讯作者:
Schaefer, AT
影响因子:
25
作者:
Friedrich, RW;Habermann, CJ;Laurent, G
通讯作者:
Laurent, G
影响因子:
16.2
作者:
Franks, KM;Isaacson, JS
通讯作者:
Isaacson, JS
DOI:
10.1523/jneurosci.2747-10.2010
发表时间:
2010-10-20
期刊:
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子:
--
作者:
Apicella A;Yuan Q;Scanziani M;Isaacson JS
通讯作者:
Isaacson JS
影响因子:
25
作者:
Gao, Yuan;Strowbridge, Ben W.
通讯作者:
Strowbridge, Ben W.