Medial entorhinal cortex lesions only partially disrupt hippocampal place cells and hippocampus-dependent place memory.
Medial entorhinal cortex lesions only partially disrupt hippocampal place cells and hippocampus-dependent place memory.
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DOI：
10.1016/j.celrep.2014.10.009
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发表时间：
2014-11-06
期刊：
影响因子：
8.8
通讯作者：
Clark RE
中科院分区：
文献类型：
--
作者：
Hales JB;Schlesiger MI;Leutgeb JK;Squire LR;Leutgeb S;Clark RE
内嗅皮层为海马体提供主要皮层投射，海马体是对记忆至关重要的大脑结构。然而，目前尚不清楚内侧内嗅皮层（MEC）细胞的精确放电模式如何影响海马生理和海马依赖性行为。我们发现 MEC 的双侧完全损伤导致活跃海马细胞比例较低。其余的活跃单元具有位置场，但空间精度降低，长期空间稳定性降低。此外，MEC 大鼠在获得水迷宫方面与海马大鼠一样受损，而 MEC 和海马同时受损的大鼠的缺陷甚至更大。然而，MEC 大鼠在其他依赖海马体的任务上并没有受到损害，包括那些记住物体位置或背景的任务。因此，MEC 并不是所有类型的空间编码所必需的，也不是所有类型的海马依赖性记忆所必需的，但对于位置记忆的正常获取是必需的。
Entorhinal cortex provides the primary cortical projections to the hippocampus, a brain structure critical for memory. However, it remains unclear how the precise firing patterns of medial entorhinal cortex (MEC) cells influence hippocampal physiology and hippocampus-dependent behavior. We found that complete bilateral lesions of MEC resulted in a lower proportion of active hippocampal cells. The remaining active cells had place fields, but with decreased spatial precision and decreased long-term spatial stability. In addition, MEC rats were as impaired at acquiring the watermaze as hippocampus rats, while rats with combined MEC and hippocampal lesions had an even greater deficit. However, MEC rats were not impaired on other hippocampus-dependent tasks, including those in which an object location or context was remembered. Thus, MEC is not necessary for all types of spatial coding, nor for all types of hippocampus-dependent memory, but is necessary for the normal acquisition of place memory.
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