The role of the primary sensorimotor system in generalized epilepsy: Evidence from the cerebello-cerebral functional integration.
The role of the primary sensorimotor system in generalized epilepsy: Evidence from the cerebello-cerebral functional integration.
复制标题
DOI：
10.1002/hbm.26551
复制
发表时间：
2024-01
影响因子：
4.8
通讯作者：
Luo, Cheng
中科院分区：
文献类型：
--
作者：
Chen, Junxia;Jiang, Sisi;Lu, Bao;Liao, Jiangyan;Yang, Zhihuan;Li, Hechun;Pei, Haonan;Li, Jianfu;Iturria-Medina, Yasser;Yao, Dezhong;Luo, Cheng
关键词：
小脑和大脑之间的相互作用广泛参与从运动处理到高级认知和情感处理的功能。由于运动症状，全身性强直阵挛性癫痫发作的特发性全身性癫痫 (IGE) 患者已被认为与运动异常相关，但小脑-大脑回路的功能相互作用仍知之甚少。收集了 101 名 IGE 患者和 106 名健康对照者的静息态功能磁共振成像数据。联系了大脑皮层和小脑之间基于体素的功能连接（FC）。应用功能梯度和独立成分分析来评估基于体素的 FC 上的小脑-大脑功能整合。小脑运动成分进一步与小脑梯度相关。结果显示小脑运动功能模块与脑运动成分密切相关。在 IGE 患者的运动模块中观察到大脑运动成分与小脑的映射发生改变。此外，患者还表现出运动模块和认知模块之间的小脑-大脑功能梯度受压。有趣的是，运动成分对梯度的贡献在患者双侧初级感觉运动成分之间是不平衡的：在优势半球初级感觉运动的小脑认知模块中观察到增加，但在非优势半球初级感觉运动的小脑认知模块中发现减少。目前的研究结果表明，大脑初级运动系统影响小脑的层次结构，并为了解 IGE 患者运动功能异常的功能整合证据做出了重大贡献。这项研究调查了小脑-大脑回路的功能相互作用，揭示了特发性全身性癫痫中脑运动成分到小脑的映射改变以及运动和认知模块之间的小脑梯度压缩，这意味着整合可能不足以协同处理患者的感觉运动信息。
The interaction between cerebellum and cerebrum participates widely in function from motor processing to high‐level cognitive and affective processing. Because of the motor symptom, idiopathic generalized epilepsy (IGE) patients with generalized tonic–clonic seizure have been recognized to associate with motor abnormalities, but the functional interaction in the cerebello–cerebral circuit is still poorly understood. Resting‐state functional magnetic resonance imaging data were collected for 101 IGE patients and 106 healthy controls. The voxel‐based functional connectivity (FC) between cerebral cortex and the cerebellum was contacted. The functional gradient and independent components analysis were applied to evaluate cerebello–cerebral functional integration on the voxel‐based FC. Cerebellar motor components were further linked to cerebellar gradient. Results revealed cerebellar motor functional modules were closely related to cerebral motor components. The altered mapping of cerebral motor components to cerebellum was observed in motor module in patients with IGE. In addition, patients also showed compression in cerebello–cerebral functional gradient between motor and cognition modules. Interestingly, the contribution of the motor components to the gradient was unbalanced between bilateral primary sensorimotor components in patients: the increase was observed in cerebellar cognitive module for the dominant hemisphere primary sensorimotor, but the decrease was found in the cerebellar cognitive module for the nondominant hemisphere primary sensorimotor. The present findings suggest that the cerebral primary motor system affects the hierarchical architecture of cerebellum, and substantially contributes to the functional integration evidence to understand the motor functional abnormality in IGE patients. This study investigated the functional interaction in the cerebello–cerebral circuit and revealed the altered mapping of cerebral motor components to cerebellum and the compressed cerebellar gradient between motor and cognition modules in idiopathic generalized epilepsy, implicating that the integration might be insufficient in collaborative processing of sensorimotor information in patients.
登录
查看更多内容
衰老大脑中内在网络的偏侧化暗示了认知训练的影响
影响因子：
4.8
作者：
Luo C;Zhang X;Cao X;Gan Y;Li T;Cheng Y;Cao W;Jiang L;Yao D;Li C
通讯作者：
Li C
影响因子：
25
作者：
King M;Hernandez-Castillo CR;Poldrack RA;Ivry RB;Diedrichsen J
通讯作者：
Diedrichsen J
影响因子：
2.7
作者：
Fine, EJ;Ionita, CC;Lohr, L
通讯作者：
Lohr, L
DOI：
10.1073/pnas.1608282113
发表时间：
2016-11-01
影响因子：
11.1
作者：
Margulies, Daniel S.;Ghosh, Satrajit S.;Smallwood, Jonathan
通讯作者：
Smallwood, Jonathan
影响因子：
5.7
作者：
Guell X;Gabrieli JDE;Schmahmann JD
通讯作者：
Schmahmann JD