Cortical Surface Area Rather Than Cortical Thickness Potentially Differentiates Radiation Encephalopathy at Early Stage in Patients With Nasopharyngeal Carcinoma.
Cortical Surface Area Rather Than Cortical Thickness Potentially Differentiates Radiation Encephalopathy at Early Stage in Patients With Nasopharyngeal Carcinoma.
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皮质表面积而非皮质厚度可能有助于区分鼻咽癌患者的早期放射性脑病
DOI：
10.3389/fnins.2018.00599
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发表时间：
2018
影响因子：
4.3
通讯作者：
Zhang YC
中科院分区：
文献类型：
--
作者：
Zhang YM;Chen MN;Yi XP;Li L;Gao JM;Zhang JL;Yuan XR;Zhang N;Liu LZ;Cai PQ;Chen BT;Zee C;Liao WH;Zhang YC
放射性脑病是鼻咽癌放疗后最严重的并发症之一。然而，早期RE的形态学变化研究得不够。我们的目的是调查鼻咽癌患者的皮质厚度和表面积的变化与RE或没有在随访。共168名NPC患者在RT前（n = 56）或RT后（n = 112）的不同时间接受了单次扫描和分析。我们进一步根据RT后分析的时间（RT后6个月内和RT后7 -12个月）或分析中是否检测到RE体征（RTRE后在随访中证实）将RT后NPC患者分为三组。我们将皮质厚度和表面积的顶点分析限制在双侧颞叶。有趣的是，我们发现在随访组中，随着RT后时间的增加，在RTRE后颞叶皮质表面积逐渐增加，这与组间结果一致，即在随访组中，RTRE后皮质表面积相对于RT前组和6个月内RTRE后组显著增加。相比之下，在皮质厚度结果中未观察到这种趋势。我们的结论是，皮质表面积，而不是皮质厚度，可能作为一个潜在的生物标志物，早期诊断RE。
Radiation encephalopathy (RE) is one of the most severe complications in nasopharyngeal carcinoma (NPC) patients after radiotherapy (RT). However, the morphological alteration of early RE is insufficiently investigated. We aimed to investigate the cortical thickness and surface area alterations in NPC patients with or without RE in the follow-up. A total of 168 NPC patients each underwent a single scan and analysis at various times either Pre-RT (n = 56) or Post-RT (n = 112). We further divided the Post-RT NPC patients into three groups based on the time of the analysis following RT (Post-RTwithin 6 months and Post-RT7-12 months) or whether RE signs were detected in the analysis (Post-RTRE proved in follow-up). We confined the vertex-wise analyses of the cortical thickness and surface area to the bilateral temporal lobes. Interestingly, we revealed a gradual increase in the cortical surface area of the temporal lobe with increasing time after RT within the Post-RTRE proved in follow-up group, consistent with the between-group findings, which showed a significant increase in cortical surface area in the Post-RTRE proved in follow-up group relative to the Pre-RT group and the Post-RTwithin 6 months group. By contrast, such a trend was not observed in the cortical thickness findings. We concluded that the cortical surface area, rather than cortical thickness, may serve as a potential biomarker for early diagnosis of RE.
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影响因子：
4.2
作者：
Mensen, Vincent T.;Wierenga, Lara M.;van Dijk, Sarai;Rijks, Yvonne;Oranje, Bob;Mandl, Rene C. W.;Durston, Sarah
通讯作者：
Durston, Sarah
影响因子：
5.7
作者：
Jubault, Thomas;Gagnon, Jean-Francois;Monchi, Oury
通讯作者：
Monchi, Oury
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
3.7
作者：
Narr, KL;Bilder, RM;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
6.9
作者：
Cremers HR;Veer IM;Spinhoven P;Rombouts SA;Yarkoni T;Wager TD;Roelofs K
通讯作者：
Roelofs K