Dorsolateral striatal lesions impair navigation based on landmark-goal vectors but facilitate spatial learning based on a "cognitive map".
Dorsolateral striatal lesions impair navigation based on landmark-goal vectors but facilitate spatial learning based on a "cognitive map".
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DOI：
10.1101/lm.037077.114
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
McGregor A
中科院分区：
文献类型：
--
作者：
Kosaki Y;Poulter SL;Austen JM;McGregor A
在三个实验中，研究了大鼠在水迷宫中解决空间任务变化的多个记忆系统之间的相互作用的性质。在整个训练过程中，大鼠能够通过学习地标-目标向量，在距离迷宫内地标固定的距离和方向上找到一个淹没的平台。迷宫外的线索也可用于标准的地方学习，或“认知映射”，但这些线索只在每个会话中有效，因为平台的位置在会话之间与迷宫内的地标一起在游泳池周围移动。因此，动物可以通过从各个阶段的地标获取一致的向量或通过参考迷宫外线索在每个阶段快速编码新的平台位置来学习平台的位置。兴奋性毒性损伤的背外侧纹状体受损向量为基础的学习，但促进认知地图为基础的快速学习时，extramaze线索相对较差（实验1），但不是当他们更显着（实验2和3）。病变效应与线索可用性相互作用的方式与当前导航任务中涉及的记忆系统在功能上是合作的，但在本质上是竞争性的这一观点是一致的。
In three experiments, the nature of the interaction between multiple memory systems in rats solving a variation of a spatial task in the water maze was investigated. Throughout training rats were able to find a submerged platform at a fixed distance and direction from an intramaze landmark by learning a landmark-goal vector. Extramaze cues were also available for standard place learning, or “cognitive mapping,” but these cues were valid only within each session, as the position of the platform moved around the pool between sessions together with the intramaze landmark. Animals could therefore learn the position of the platform by taking the consistent vector from the landmark across sessions or by rapidly encoding the new platform position on each session with reference to the extramaze cues. Excitotoxic lesions of the dorsolateral striatum impaired vector-based learning but facilitated cognitive map-based rapid place learning when the extramaze cues were relatively poor (Experiment 1) but not when they were more salient (Experiments 2 and 3). The way the lesion effects interacted with cue availability is consistent with the idea that the memory systems involved in the current navigation task are functionally cooperative yet associatively competitive in nature.
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DOI：
10.1037/h0061366
发表时间：
1948-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BLODGETT, HC;MCCUTCHAN, K
通讯作者：
MCCUTCHAN, K
影响因子：
--
作者：
BLODGETT, HC;MCCUTCHAN, K
通讯作者：
MCCUTCHAN, K
影响因子：
3
作者：
JARRARD, LE
通讯作者：
JARRARD, LE
影响因子：
1.9
作者：
Horne, Murray R.;Iordanova, Mihaela D.;Pearce, John M.
通讯作者：
Pearce, John M.
影响因子：
3.7
作者：
Killcross, S;Coutureau, E
通讯作者：
Coutureau, E