Associations between neighborhood greenspace and brain imaging measures in non-demented older adults: the Cardiovascular Health Study.
Associations between neighborhood greenspace and brain imaging measures in non-demented older adults: the Cardiovascular Health Study.
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社区绿地与非痴呆老年人脑成像测量之间的关联：心血管健康研究
DOI：
10.1007/s00127-020-02000-w
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发表时间：
2021-09
影响因子：
4.4
通讯作者：
Longstreth WT
中科院分区：
文献类型：
--
作者：
Besser LM;Lovasi GS;Michael YL;Garg P;Hirsch JA;Siscovick D;Hurvitz P;Biggs ML;Galvin JE;Bartz TM;Longstreth WT
更多的社区绿地与大脑健康有关，包括老年人更好的认知能力和更低的阿尔茨海默病几率。我们调查了社区绿地与脑核磁共振成像（MRI）测量之间的关系，以及性别或载脂蛋白E基因型（APOE）的潜在影响。载脂蛋白E基因型是阿尔茨海默病的一个危险因素。我们从纵向、基于人群的心血管健康研究（CHS）中获得了65岁或以上的非痴呆参与者样本（n= 1125）。绿色空间数据来自国家土地覆盖数据集。调整后的多变量线性回归估计了MRI前5年邻里绿地与左右海马体积、心室大小和白质高负荷的10分等级之间的关联。相互作用项测试了APOE基因型和性别对效应的影响。CHS数据（1989-1999）于2020年获得/分析。参与者平均年龄为79岁（标准差[SD]=4）， 58%为女性，11%为非白种人。平均社区绿地占38% （SD=28%）。MRI前5年附近绿地的比例越大，与较低的心室分级呈边缘相关（估计值：−0.30；95%可信区间：−0.61,0.00）。我们没有观察到绿色空间和其他MRI结果测量之间的关联，也没有证据表明APOE基因型和性别会改变效果。这项研究表明，更大的绿色空间和更小的脑室扩大之间可能存在关联，脑室扩大是反映全球脑萎缩的一种指标。如果在其他纵向队列研究中得到证实，改善社区绿地的干预措施和政策可能有助于保持老年人的大脑健康。
Greater neighborhood greenspace has been associated with brain health, including better cognition and lower odds of Alzheimer’s disease in older adults. We investigated associations between neighborhood greenspace and brain-based magnetic resonance imaging (MRI) measures and potential effect modification by sex or apolipoprotein E genotype (APOE), a risk factor for Alzheimer’s disease. We obtained a sample of non-demented participants 65 years or older (n=1,125) from the longitudinal, population-based Cardiovascular Health Study (CHS). Greenspace data were derived from the National Land Cover Dataset. Adjusted multivariable linear regression estimated associations between neighborhood greenspace five years prior to the MRI and left and right hippocampal volume and 10-point grades of ventricular size and burden of white matter hyperintensity. Interaction terms tested effect modification by APOE genotype and sex. CHS data (1989–1999) were obtained/analyzed in 2020. Participants were on average 79 years old (standard deviation [SD]=4)), 58% were female, and 11% were non-white race. Mean neighborhood greenspace was 38% (SD=28%). Greater proportion of greenspace in the neighborhood five years before MRI was borderline associated with lower ventricle grade (estimate: −0.30; 95% confidence interval: −0.61, 0.00). We observed no associations between greenspace and the other MRI outcome measures and no evidence of effect modification by APOE genotype and sex. This study suggests a possible association between greater greenspace and less ventricular enlargement, a measure reflecting global brain atrophy. If confirmed in other longitudinal cohort studies, interventions and policies to improve community greenspaces may help to maintain brain health in older age.
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影响因子：
10.4
作者：
Dadvand P;Tischer C;Estarlich M;Llop S;Dalmau-Bueno A;López-Vicente M;Valentín A;de Keijzer C;Fernández-Somoano A;Lertxundi N;Rodriguez-Dehli C;Gascon M;Guxens M;Zugna D;Basagaña X;Nieuwenhuijsen MJ;Ibarluzea J;Ballester F;Sunyer J
通讯作者：
Sunyer J
DOI：
10.3233/jad-170658
发表时间：
2018
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Cleary EG;Cifuentes M;Grinstein G;Brugge D;Shea TB
通讯作者：
Shea TB
影响因子：
2.4
作者：
Fletcher, Evan;Gavett, Brandon;Mungas, Dan
通讯作者：
Mungas, Dan
影响因子：
5.4
作者：
Cherrie, Mark P. C.;Shortt, Niamh K.;Pearce, Jamie R.
通讯作者：
Pearce, Jamie R.
影响因子：
2.6
作者：
Chaddock-Heyman, Laura;Erickson, Kirk I.;Voss, Michelle W.;Powers, John P.;Knecht, Anya M.;Pontifex, Matthew B.;Drollette, Eric S.;Moore, R. Davis;Raine, Lauren B.;Scudder, Mark R.;Hillman, Charles H.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.