Circulating Omega-6 and Omega-3 Polyunsaturated Fatty Acids in Painful Temporomandibular Disorder and Low Back Pain.
Circulating Omega-6 and Omega-3 Polyunsaturated Fatty Acids in Painful Temporomandibular Disorder and Low Back Pain.
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DOI：
10.1016/j.jpain.2022.05.008
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发表时间：
2022-10
期刊：
影响因子：
4
通讯作者：
Slade, Gary D.
中科院分区：
文献类型：
--
作者：
Sanders, Anne E.;Weatherspoon, E. Diane;Ehrmann, Brandie M.;Soma, Paul S.;Shaikh, Saame R.;Preisser, John S.;Ohrbach, Richard;Fillingim, Roger B.;Slade, Gary D.
临床前研究表明，长链多不饱和脂肪酸（PUFA）代谢产物对炎症和伤害感受具有相反的作用。Omega-6（n-6）PUFA放大这两个过程，而omega-3（n-3）PUFA抑制它们。这项横断面研究检查了循环红细胞中PUFAs与两种慢性特发性疼痛疾病之间的关系：颞下颌关节紊乱病（TMD）和腰痛，以社区为基础的样本为503名美国成年人。存在或不存在的TMD和腰痛，分别由临床检查和建立的筛选问题的答复确定。液相色谱串联质谱法定量PUFA。在多变量logistic回归模型中，n-6/n-3长链PUFA的比例越高，TMD（比值比（OR）=1.75，95%置信限（CL）：1.16，2.64）和腰痛（OR=1.63，95% CL：1.07，2.49）的几率越大。较高水平的原伤害性n-6长链花生四烯酸与女性两种疼痛状况的可能性更大有关，但与男性无关。较高水平的抗伤害性长链n-3 PUFA二十碳五烯酸和二十二碳六烯酸与男性两种疼痛状况的概率较低相关，但与女性无关。由于全身性炎症不是这些疾病的标志，PUFA可能通过其他机制影响特发性疼痛。
Pre-clinical studies demonstrate opposing effects of long-chain polyunsaturated fatty acid (PUFA) metabolites on inflammation and nociception. Omega-6 (n-6) PUFAs amplify both processes while omega-3 (n-3) PUFAs inhibit them. This cross-sectional study examined relationships between PUFAs in circulating erythrocytes and two chronic idiopathic pain conditions: temporomandibular disorder (TMD) and low back pain in a community-based sample of 503 U.S. adults. Presence or absence of TMD and low back pain, respectively, were determined by clinical examination and by responses to established screening questions. Liquid chromatography tandem mass spectrometry quantified PUFAs. In multivariable logistic regression models, a higher ratio of n-6/n-3 long-chain PUFAs was associated with greater odds of TMD (odds ratio ((OR)=1.75, 95% confidence limits (CL): 1.16, 2.64) and low back pain (OR=1.63, 95% CL: 1.07, 2.49). Higher levels of the pronociceptive n-6 long-chain arachidonic acid were associated with greater probability of both pain conditions for women, but not men. Higher levels of the antinociceptive long-chain n-3 PUFAs eicosapentaenoic and docosahexaenoic acids were associated with lower probability of both pain conditions for men, but not women. As systemic inflammation is not a hallmark of these conditions, PUFAs may influence idiopathic pain through other mechanisms.
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