H3N2 influenza virus transmission from swine to turkeys, United States.
H3N2 influenza virus transmission from swine to turkeys, United States.
复制标题
DOI：
10.3201/eid1012.040581
复制
发表时间：
2004-12
影响因子：
11.8
通讯作者：
Webby RJ
中科院分区：
文献类型：
--
作者：
Choi YK;Lee JH;Erickson G;Goyal SM;Joo HS;Webster RG;Webby RJ
猪类H3N2流感病毒从美国两个地理位置不同的火鸡养殖场分离出来。1998年，一种新型H3N2重组病毒在美国猪群中出现。我们报告了2003年在美国两个地理位置遥远的农场中这种病毒在火鸡中的种间传播。考虑到该病毒的重组能力和火鸡对禽流感病毒感染的易感性，这一事件令人关注。H3N2分离株A/turkey/NC/16108/03和A/turkey/MN/764/03的8个基因片段核苷酸序列同源性为98.0% ~ 99.9%。火鸡分离物的所有蛋白质成分序列与猪H3N2病毒具有97%至98%的同源性，从而证明猪到火鸡的种间传播。火鸡的分离株比它们最接近的猪的分离株更能适应鸟类宿主，这表明病毒已经开始在新的宿主中进化。从火鸡身上分离出类似猪的H3N2流感病毒，引发了人们对产生可能影响人类的新型病毒的新担忧。
Swinelike H3N2 influenza viruses were isolated from two geographically distinct turkey farms in the United States. In 1998, a novel H3N2 reassortant virus emerged in the United States swine population. We report the interspecies transmission of this virus to turkeys in two geographically distant farms in the United States in 2003. This event is of concern, considering the reassortment capacity of this virus and the susceptibility of turkey to infection by avian influenza viruses. Two H3N2 isolates, A/turkey/NC/16108/03 and A/turkey/MN/764/03, had 98.0% to 99.9% nucleotide sequence identity to each other in all eight gene segments. All protein components of the turkey isolates had 97% to 98% sequence identity to swine H3N2 viruses, thus demonstrating interspecies transmission from pigs to turkeys. The turkey isolates were better adapted to avian hosts than were their closest swine counterparts, which suggests that the viruses had already begun to evolve in the new host. The isolation of swine-like H3N2 influenza viruses from turkeys raises new concerns for the generation of novel viruses that could affect humans.
登录
查看更多内容
影响因子：
5.4
作者：
Guan, Y;Shortridge, KF;Peiris, M
通讯作者：
Peiris, M
影响因子：
1.4
作者：
Sung, HW;Reddy, SM;Fadly, AM
通讯作者：
Fadly, AM
影响因子：
56.9
作者：
HINSHAW, VS;WEBSTER, RG;SENNE, DA
通讯作者：
SENNE, DA
影响因子：
3.8
作者：
CASTRUCCI, MR;CAMPITELLI, L;DONATELLI, I
通讯作者：
DONATELLI, I
影响因子：
5
作者：
Choi, YK;Goyal, SM;Joo, HS
通讯作者：
Joo, HS