Prenatal stress: role in psychotic and depressive diseases.
Prenatal stress: role in psychotic and depressive diseases.
复制标题
DOI：
10.1007/s00213-010-2035-0
复制
发表时间：
2011-03
影响因子：
3.4
通讯作者：
Koenig, James I.
中科院分区：
文献类型：
--
作者：
Markham, Julie A.;Koenig, James I.
关键词：
神经元的诞生、它们迁移到大脑中适当位置以及它们适当突触接触的建立主要发生在产前时期。妊娠期间的环境压力源会对大脑发育产生重大影响，从而导致神经精神疾病的发病机制，例如抑郁症和包括精神分裂症在内的精神病。本文的目的是介绍最近关于产前暴露于妊娠应激源对胎儿大脑发育的影响的临床前研究，并讨论它们与精神疾病的神经生物学基础的相关性。重点是母亲的免疫激活、心理压力和营养不良，因为大量的临床文献支持它们在神经精神疾病的病因学中的作用。产前母体免疫激活、病毒感染、不可预测的心理压力和营养不良似乎都会促进暴露后代的行为异常的发展，这些异常可能与精神分裂症和精神病的症状领域相关，包括感觉运动门控、信息处理、认知、社会功能和皮质下多巴胺能亢进。在一些模型系统中也观察到与抑郁相关的表型，例如习得性无助或焦虑。这些变化似乎是由胎儿室中促炎细胞因子和/或皮质类固醇的存在介导的，这些细胞因子和/或皮质类固醇改变了与这些行为有关的神经解剖学底物的发育。产前暴露于环境压力源会改变大脑发育的轨迹，可用于生成动物制剂，这些制剂可能有助于了解几种人类神经精神疾病的病理生理过程。
The birth of neurons, their migration to appropriate positions in the brain, and their establishment of the proper synaptic contacts happen predominately during the prenatal period. Environmental stressors during gestation can exert a major impact on brain development and thereby contribute to the pathogenesis of neuropsychiatric illnesses, such as depression and psychotic disorders including schizophrenia. The objectives here are to present recent preclinical studies of the impact of prenatal exposure to gestational stressors on the developing fetal brain and discuss their relevance to the neurobiological basis of mental illness. The focus is on maternal immune activation, psychological stresses, and malnutrition, due to the abundant clinical literature supporting their role in the etiology of neuropsychiatric illnesses. Prenatal maternal immune activation, viral infection, unpredictable psychological stress, and malnutrition all appear to foster the development of behavioral abnormalities in exposed offspring that may be relevant to the symptom domains of schizophrenia and psychosis, including sensorimotor gating, information processing, cognition, social function, and subcortical hyperdopaminergia. Depression-related phenotypes, such as learned helplessness or anxiety, are also observed in some model systems. These changes appear to be mediated by the presence of proinflammatory cytokines and/or corticosteroids in the fetal compartment that alter the development the neuroanatomical substrates involved in these behaviors. Prenatal exposure to environmental stressors alters the trajectory of brain development and can be used to generate animal preparations that may be informative in understanding the pathophysiological processes involved in several human neuropsychiatric disorders.
登录
查看更多内容
影响因子：
4.8
作者：
Bowman, RE;MacLusky, NJ;Luine, VN
通讯作者：
Luine, VN
影响因子：
4.5
作者：
Broadbelt, K;Byne, W;Jones, LB
通讯作者：
Jones, LB
影响因子：
4.3
作者：
Brown, Alan S
通讯作者：
Brown, Alan S
影响因子：
17.7
作者：
Brown, AS;van Os, J;Susser, ES
通讯作者：
Susser, ES
DOI：
10.1017/s1121189x00007946
发表时间：
2005-10-01
期刊：
EPIDEMIOLOGIA E PSICHIATRIA SOCIALE-AN INTERNATIONAL JOURNAL FOR EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
影响因子：
--
作者：
Bresnahan, M;Schaefer, CA;Susser, ES
通讯作者：
Susser, ES