Antimicrobial Resistance in Bacterial Poultry Pathogens: A Review.
Antimicrobial Resistance in Bacterial Poultry Pathogens: A Review.
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DOI：
10.3389/fvets.2017.00126
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发表时间：
2017
影响因子：
3.2
通讯作者：
Carrique-Mas JJ
中科院分区：
文献类型：
--
作者：
Nhung NT;Chansiripornchai N;Carrique-Mas JJ
抗菌素耐药性(AMR)是一种全球性的健康威胁，而抗菌剂的使用和动物生产中的AMR是其来源之一。家禽是世界上消费最广泛的肉类之一。家禽群通常是在密集条件下饲养的，使用大量抗菌剂来预防和治疗疾病，以及促进生长。具有抗药性的禽类病原体可能导致治疗失败，导致经济损失，但也可能是耐药细菌/基因(包括人畜共患病细菌)的来源，可能对人类健康构成威胁。本文综述了12种禽类病原菌的AMR研究资料，这些病原菌包括禽类致病性大肠杆菌(APEC)、鸡白鼠沙门氏菌/鸡群沙门氏菌、多杀性巴氏杆菌、副鸡副伤寒杆菌、加利杆菌、变态杆菌、鼻气管口杆菌、禽博氏杆菌、产气荚膜梭菌、支原体、rhusiopathiae和鸭疫里默氏杆菌。许多研究表明，随着时间的推移，对鸡白肺杆菌、鸡败血杆菌和鸡毒杆菌的耐药性会增加。在肠杆菌科细菌中，APEC分离株的AMR水平明显高于新城疫/鸡冠杆菌，研究中对氨苄西林、阿莫西林、四环素的耐药率超过80%。在革兰氏阴性非肠杆菌科病原菌中，ORT的表型耐药水平最高，对复方新诺明、恩诺沙星、庆大霉素、阿莫西林和头孢硫呋喃的AMR中位数均超过50%。相比之下，多杀性巴氏杆菌分离株对所有抗菌药的耐药率均低于20%。这项研究突出了方法学以及表型抗菌素敏感性测试和结果解释标准方面的相当大的差异。有必要加强努力，协调检测做法，促进免费获取有关AMR的数据，以便改进治疗指南，并监测家禽细菌性病原体中AMR的演变。
Antimicrobial resistance (AMR) is a global health threat, and antimicrobial usage and AMR in animal production is one of its contributing sources. Poultry is one of the most widespread types of meat consumed worldwide. Poultry flocks are often raised under intensive conditions using large amounts of antimicrobials to prevent and to treat disease, as well as for growth promotion. Antimicrobial resistant poultry pathogens may result in treatment failure, leading to economic losses, but also be a source of resistant bacteria/genes (including zoonotic bacteria) that may represent a risk to human health. Here we reviewed data on AMR in 12 poultry pathogens, including avian pathogenic Escherichia coli (APEC), Salmonella Pullorum/Gallinarum, Pasteurella multocida, Avibacterium paragallinarum, Gallibacterium anatis, Ornitobacterium rhinotracheale (ORT), Bordetella avium, Clostridium perfringens, Mycoplasma spp., Erysipelothrix rhusiopathiae, and Riemerella anatipestifer. A number of studies have demonstrated increases in resistance over time for S. Pullorum/Gallinarum, M. gallisepticum, and G. anatis. Among Enterobacteriaceae, APEC isolates displayed considerably higher levels of AMR compared with S. Pullorum/Gallinarum, with prevalence of resistance over >80% for ampicillin, amoxicillin, tetracycline across studies. Among the Gram-negative, non-Enterobacteriaceae pathogens, ORT had the highest levels of phenotypic resistance with median levels of AMR against co-trimoxazole, enrofloxacin, gentamicin, amoxicillin, and ceftiofur all exceeding 50%. In contrast, levels of resistance among P. multocida isolates were less than 20% for all antimicrobials. The study highlights considerable disparities in methodologies, as well as in criteria for phenotypic antimicrobial susceptibility testing and result interpretation. It is necessary to increase efforts to harmonize testing practices, and to promote free access to data on AMR in order to improve treatment guidelines as well as to monitor the evolution of AMR in poultry bacterial pathogens.
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影响因子：
2.7
作者：
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通讯作者：
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2.6
作者：
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通讯作者：
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