The relationship between air pollution and low birth weight: effects by mother's age, infant sex, co-pollutants, and pre-term births.
The relationship between air pollution and low birth weight: effects by mother's age, infant sex, co-pollutants, and pre-term births.
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DOI：
10.1088/1748-9326/3/4/044003
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发表时间：
2008-10
期刊：
影响因子：
--
通讯作者：
Belanger K
中科院分区：
文献类型：
--
作者：
Bell ML;Ebisu K;Belanger K
之前，我们确定了1999-2002年康涅狄格州和马萨诸塞州母亲的空气污染暴露与出生体重之间的关系。其他研究也发现了影响，尽管结果不一致。我们探讨了早期工作中的潜在不确定性，并进一步探讨了空气污染与PM10，PM2.5，CO，NO2和SO2的出生体重之间的关系。我们具体调查了：（1）年轻（≤24岁）和年长（≥40岁）母亲的婴儿是否特别容易受到空气污染对出生体重的影响;（2）空气污染和出生体重之间的关系是否因婴儿性别而异;（3）混合污染物和污染物测量频率差异的混淆;以及（4）观察到的关联是否受到早产的影响。研究结果并没有表明，根据母亲的年龄或婴儿的性别，空气污染和出生体重之间的关系更容易受到影响。结果是强大的早产儿和共污染物调整排除，虽然样本量减少了一些污染物对。这些发现为空气污染和出生体重之间的关系提供了额外的证据，并且没有根据婴儿性别或母亲的年龄确定易感亚群。最后，我们讨论了空气污染和妊娠结局研究中的关键挑战。
Previously we identified associations between the mother’s air pollution exposure and birth weight for births in Connecticut and Massachusetts from 1999–2002. Other studies also found effects, though results are inconsistent. We explored potential uncertainties in earlier work and further explored associations between air pollution and birth weight for PM10, PM2.5, CO, NO2, and SO2. Specifically we investigated: (1) whether infants of younger (≤24 years) and older (≥40 years) mothers are particularly susceptible to air pollution’s effects on birth weight; (2) whether the relationship between air pollution and birth weight differed by infant sex; (3) confounding by co-pollutants and differences in pollutants’ measurement frequencies; and (4) whether observed associations were influenced by inclusion of pre-term births. Findings did not indicate higher susceptibility to the relationship between air pollution and birth weight based on the mother’s age or the infant’s sex. Results were robust to exclusion of pre-term infants and co-pollutant adjustment, although sample size decreased for some pollutant pairs. These findings provide additional evidence for the relationship between air pollution and birth weight, and do not identify susceptible sub-populations based on infant sex or mother’s age. We conclude with discussion of key challenges in research on air pollution and pregnancy outcomes.
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