Blunted HPA axis response to stress is related to a persistent Dysregulation Profile in youth.
Blunted HPA axis response to stress is related to a persistent Dysregulation Profile in youth.
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DOI：
10.1016/j.biopsycho.2013.04.002
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发表时间：
2013-07
影响因子：
2.6
通讯作者：
van der Ende, Jan
中科院分区：
文献类型：
--
作者：
Ayer, Lynsay;Greaves-Lord, Kirstin;Althoff, Robert R.;Hudziak, James J.;Dieleman, Gwendolyn C.;Verhulst, Frank C.;van der Ende, Jan
儿童行为检查表失调档案（DP）在青少年已被证明是一个预测精神病理以后的生活。我们检查了青少年的下丘脑垂体-肾上腺（HPA）轴的活性与缓解，新的，持续的，和没有DP。数据来自489名年轻人（47%的男孩）参加荷兰的纵向一般人口研究（波1平均年龄=11.5，波2=14.2）。我们比较了青年DP在第1波、第2波、两个波和没有波时的皮质醇昼夜模式和对实验室应激范式的反应水平。与其他两组相比，仅在波2或在两个时间点都有DP的年轻人对压力的皮质醇反应迟钝。皮质醇的日活动没有组间或性别差异。需要更多的研究来确定DP症状和下丘脑轴功能之间的关系如何随时间变化。
The Child Behavior Checklist Dysregulation Profile (DP) in youth has been shown to be a predictor of psychopathology later in life. We examined the activity of the Hypothalamic Pituitary Adrenal (HPA) axis in youth with remitted, new, persistent, and no DP. Data from 489 youth (47% boys) participating in a Dutch longitudinal general population study were included (Wave 1 mean age=11.5, Wave 2=14.2). Wave 2 diurnal cortisol patterns and levels in response to a laboratory stress paradigm were compared in youth with DP at Wave 1 only, Wave 2 only, both Waves, and neither Wave. Youth with the DP at Wave 2 only or at both time points showed blunted cortisol responses to stress relative to the other two groups. There were no group or sex differences in diurnal cortisol activity. More research is needed to determine how the association between DP symptoms and HPA axis functioning changes over time.
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