Sleep deprivation impairs spatial retrieval but not spatial learning in the non-human primate grey mouse lemur.
Sleep deprivation impairs spatial retrieval but not spatial learning in the non-human primate grey mouse lemur.
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DOI：
10.1371/journal.pone.0064493
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Aujard F
中科院分区：
文献类型：
--
作者：
Rahman A;Languille S;Lamberty Y;Babiloni C;Perret M;Bordet R;Blin OJ;Jacob T;Auffret A;Schenker E;Richardson J;Pifferi F;Aujard F
大量对啮齿动物和人类的研究表明，睡眠促进了学习和记忆过程的不同阶段，而睡眠剥夺（SD）则损害了这些过程。在这里，我们测试的假设，SD可以改变空间学习和记忆处理的非人类灵长类动物，灰鼠狐猴（Microcebus murinus），这是一个有趣的模型老化和阿尔茨海默病（AD）。进行了两组实验。在第一组实验中，我们研究了SD在圆形平台任务中训练一天后对空间学习和记忆提取的影响。在三种不同的条件下测试了11只2至3岁的雄性鼠狐猴：没有SD作为基线参考，训练前8 h SD和测试前8 h SD。通过脑电图记录证实SD。结果表明，在训练前应用SD对学习没有影响。当在测试之前应用SD时，它会导致错误量和到达目标之前的延迟增加。在第二组实验中，我们测试了训练3天后8小时SD对空间记忆提取的影响。在这组实验中测试了20只2至3岁的雄性鼠狐猴。在这种情况下，SD不影响记忆提取。这是第一项研究，文件的SD空间记忆检索的破坏性影响，在这种灵长类动物，这可能是一个新的验证的挑战，以调查新的化合物沿着生理和病理老化的影响。
A bulk of studies in rodents and humans suggest that sleep facilitates different phases of learning and memory process, while sleep deprivation (SD) impairs these processes. Here we tested the hypothesis that SD could alter spatial learning and memory processing in a non-human primate, the grey mouse lemur (Microcebus murinus), which is an interesting model of aging and Alzheimer's disease (AD). Two sets of experiments were performed. In a first set of experiments, we investigated the effects of SD on spatial learning and memory retrieval after one day of training in a circular platform task. Eleven male mouse lemurs aged between 2 to 3 years were tested in three different conditions: without SD as a baseline reference, 8 h of SD before the training and 8 h of SD before the testing. The SD was confirmed by electroencephalographic recordings. Results showed no effect of SD on learning when SD was applied before the training. When the SD was applied before the testing, it induced an increase of the amount of errors and of the latency prior to reach the target. In a second set of experiments, we tested the effect of 8 h of SD on spatial memory retrieval after 3 days of training. Twenty male mouse lemurs aged between 2 to 3 years were tested in this set of experiments. In this condition, the SD did not affect memory retrieval. This is the first study that documents the disruptive effects of the SD on spatial memory retrieval in this primate which may serve as a new validated challenge to investigate the effects of new compounds along physiological and pathological aging.
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影响因子：
2.7
作者：
Dametto, M;Suchecki, D;Oliveira, MGM
通讯作者：
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影响因子：
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作者：
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影响因子：
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DOI：
10.1016/j.ddtec.2012.04.001
发表时间：
2013-09-01
期刊：
Drug discovery today. Technologies
影响因子：
--
作者：
Laurijssens, Bart;Aujard, Fabienne;Rahman, Anisur
通讯作者：
Rahman, Anisur
影响因子：
2
作者：
Graves, LA;Heller, EA;Abel, T
通讯作者：
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