Remodeling sensory cortical maps implants specific behavioral memory.
Remodeling sensory cortical maps implants specific behavioral memory.
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DOI：
10.1016/j.neuroscience.2013.04.038
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发表时间：
2013-08-29
期刊：
影响因子：
3.3
通讯作者：
Weinberger NM
中科院分区：
文献类型：
--
作者：
Bieszczad KM;Miasnikov AA;Weinberger NM
记忆丰富的感官细节背后的神经机制在很大程度上是未知的。一种候选机制是学习诱导的可塑性，它重塑了成人的感觉皮层。在这里，通过将3.66 kHz的音调与基底核的激活配对，模拟自然联想学习的效果，诱导大鼠初级听觉皮层（A1）张力图的扩张。A1的重塑产生了从头开始的特定行为记忆，但记忆和可塑性都不一致，配对音调的频率在A1表征中通常会下降。相反，个体受试者的扩张区域与每只动物记忆中最强的音调之间存在特定的匹配，这是由训练后的频率泛化梯度决定的。这些发现首次证明了特定神经表征可塑性的人工诱导与行为记忆的人工诱导之间的匹配。因此，结合之前和现在关于可塑性与记忆习得的检测、关联和模仿的发现，它们满足了记忆的神经基质的一个关键标准。这表明，直接重塑感觉皮层地图是足够的特异性记忆形成。
Neural mechanisms underlying the capacity of memory to be rich with sensory detail are largely unknown. A candidate mechanism is learning-induced plasticity that remodels adult sensory cortex. Here, expansion in the primary auditory cortical (A1) tonotopic map of rats was induced by pairing a 3.66 kHz tone with activation of the nucleus basalis, mimicking the effects of natural associative learning. Remodeling of A1 produced de novo specific behavioral memory, but neither memory nor plasticity were consistently at the frequency of the paired tone, which typically decreased in A1 representation. Rather, there was a specific match between individual subjects’ area of expansion and the tone that was strongest in each animal’s memory, as determined by post-training frequency generalization gradients. These findings provide the first demonstration of a match between the artificial induction of specific neural representational plasticity and artificial induction of behavioral memory. As such, together with prior and present findings for detection, correlation and mimicry of plasticity with the acquisition of memory, they satisfy a key criterion for neural substrates of memory. This demonstrates that directly remodeling sensory cortical maps is sufficient for the specificity of memory formation.
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影响因子：
25
作者：
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通讯作者：
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影响因子：
2.7
作者：
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作者：
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通讯作者：
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DOI：
10.1111/j.1460-9568.2011.07974.x
发表时间：
2012-02
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Bieszczad KM;Weinberger NM
通讯作者：
Weinberger NM
影响因子：
2.7
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通讯作者：
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