Epilepsy-predictive magnetic resonance imaging changes following experimental febrile status epilepticus: Are they translatable to the clinic?
Epilepsy-predictive magnetic resonance imaging changes following experimental febrile status epilepticus: Are they translatable to the clinic?
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DOI：
10.1111/epi.14561
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发表时间：
2018-11
期刊：
影响因子：
5.6
通讯作者：
Obenaus A
中科院分区：
文献类型：
--
作者：
Curran MM;Haddad E;Patterson KP;Choy M;Dubé CM;Baram TZ;Obenaus A
一部分患有癫痫性发热状态（FSE）的儿童在以后的生活中有发生颞叶癫痫的风险。我们寻求一种非侵入性的风险预测标志物，可以在FSE后不久，在临床上现实的时间范围内确定。在实验性（e）FSE后的几个时间点，在高场扫描仪上对大鼠幼崽进行纵向T2加权磁共振成像（T2WI MRI），然后进行长期连续脑电图。同时在3.0T临床扫描仪上进行T2WI MRI扫描。最后，慢性T2WI MRI信号的变化进行了检查，在大鼠经历了eFSE和成像月后在成年期。先前在eFSE后两小时观察到的癫痫预测T2变化持续了至少六个小时，从而能够转化为临床。与单次MRI扫描相比，重复扫描，在eFSE后创建T2弛豫时间的MRI轨迹，提供了更好的癫痫发生预测。预测信号的变化集中在边缘结构，如基底外侧和内侧杏仁核。最初在高场扫描仪上描述的T2WI MRI变化也可以在临床MRI扫描仪上测量。在大鼠中，在eFSE后数月观察到海马中T2弛豫时间的慢性升高，正如在儿童中观察到的FSE后变化。在高场和临床MRI扫描仪上，eFSE后的早期T2WI MRI变化提供了eFSE后癫痫发生的强有力的预测指标。重要的是，将急性信号变化延长至FSE后至少6小时，使其能够纳入临床研究。海马结构和相关结构内T2弛豫时间的慢性升高在人类和啮齿动物FSE中是常见的，这表明跨物种涉及类似的过程。
A subset of children with Febrile Status Epilepticus (FSE) are at risk for development of temporal lobe epilepsy later in life. We sought a non-invasive predictive marker of those at risk, that can be identified soon after FSE, within a clinically realistic timeframe. Longitudinal T2-weighted magnetic resonance imaging (T2WI MRI) of rat pups at several time points after experimental (e)FSE was performed on a high-field scanner followed by long-term continuous electroencephalography. In parallel, T2WI MRI scans were performed on a 3.0T clinical scanner. Finally, chronic T2WI MRI signal changes were examined in rats that experienced eFSE and imaged month’s later in adulthood. Epilepsy-predicting T2 changes, previously observed at two hours after eFSE, persisted for at least six hours, enabling translation to the clinic. Repeated scans, creating MRI trajectories of T2 relaxation times following eFSE provided improved prediction of epileptogenesis compared with a single MRI scan. Predictive signal changes centered on limbic structures, such as the basolateral and medial amygdala. T2WI MRI changes, originally described on high-field scanners can be also measured on clinical MRI scanners. Chronically elevated T2 relaxation times in hippocampus were observed months after eFSE in rats, as noted for post-FSE changes in children. Early T2WI MRI changes after eFSE provide a strong predictive measure of epileptogenesis following eFSE, both on high-field and clinical MRI scanners. Importantly, the extension of the acute signal changes to at least six hours after the FSE enables its inclusion in clinical studies. Chronic elevations of T2 relaxation times within the hippocampal formation and related structures are common to human and rodent FSE, suggesting that similar processes are involved across species.
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影响因子：
11.2
作者：
Hesdorffer, Dale C.;Benn, Emma K. T.;Bagiella, Emilia;Nordli, Douglas;Pellock, John;Hinton, Veronica;Shinnar, Shlomo
通讯作者：
Shinnar, Shlomo
影响因子：
5.7
作者：
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通讯作者：
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影响因子：
82.9
作者：
Chen, K;Baram, TZ;Soltesz, I
通讯作者：
Soltesz, I
影响因子：
5.3
作者：
Matsumae, M;Kurita, D;Tsugane, R
通讯作者：
Tsugane, R
影响因子：
6.1
作者：
Jansen, Jacobus F. A.;Lemmens, Evi M. P.;Hoogland, Govert
通讯作者：
Hoogland, Govert