Flow control in a laminate capillary-driven microfluidic device.
Flow control in a laminate capillary-driven microfluidic device.
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DOI：
10.1039/d0an02279a
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发表时间：
2021-03-21
期刊：
影响因子：
--
通讯作者：
Henry CS
中科院分区：
文献类型：
--
作者：
Jang I ;Kang H ;Song S ;Dandy DS ;Geiss BJ ;Henry CS
毛细管驱动的微流控装置对现场分析非常有意义，因为它们不需要外部泵，而且可以用廉价的材料制造。在毛细管驱动的设备中，纸和聚酯薄膜制成的设备是最常见的设备之一，并已在广泛的应用中使用。然而，由于毛细管力是唯一的驱动力，流动很难控制，必须使用改变几何形状等被动流动控制方法来完成各种分析应用。这项研究提出了几种新的流量控制方法，可以用于层状毛细管驱动的微流控设备，以增加可用的功能。首先，我们介绍了可以停止和启动流量的推流阀和爆破阀系统。这些阀门可以停止流动30分钟，并可以通过按压通道或向阀门区域注入其他流体来打开。接下来，我们提出了能够实现更多功能的Y形通道的流量控制方法。在一个例子中，我们演示了精确控制浓度的能力，以创建层流、梯度和完全混合的流动。在第二个例子中，通过调节入口通道的长度来控制主通道中的流速。另外，随着进口长度的增加，流动速度保持不变。最后，考察了Y型装置中的流速与通道高度和流体性质(如粘度和表面张力)的关系。与以往对毛细管驱动通道的研究一样，流速受各个参数的影响。这里介绍的流体控制工具将实现新的设计和功能，用于各种领域的低成本需求点分析。提出了适用于层状毛细管驱动微流控装置的新型流量控制方法，包括阀门控制、混合控制和流量控制。
Capillary-driven microfluidic devices are of significant interest for on-site analysis because they do not require external pumps and can be made from inexpensive materials. Among capillary-driven devices, those made from paper and polyester film are among the most common and have been used in a wide array of applications. However, since capillary forces are the only driving force, flow is difficult to control, and passive flow control methods such as changing the geometry must be used to accomplish various analytical applications. This study presents several new flow control methods that can be utilized in a laminate capillary-driven microfluidic device to increase available functionality. First, we introduce push and burst valve systems that can stop and start flow. These valves can stop flow for > 30 min and be opened by either pressing the channel or inflowing other fluids to the valve region. Next, we propose flow control methods for Y-shaped channels that enable more functions. In one example, we demonstrate the ability to accurately control concentration to create laminar, gradient, and fully mixed flows. In a second example, flow velocity in the main channel is controlled by adjusting the length of the inlet channel. In addition, the flow velocity is constant as the inlet length increases. Finally, the flow velocity in the Y-shaped device as a function of channel height and fluid properties such as viscosity and surface tension was examined. As in previous studies on capillary-driven channels, the flow rate was affected by each parameter. The fluidic control tools presented here will enable new designs and functions for low cost point of need assays across a variety of fields. We present novel flow control methods including valve, mixing control, and flow rate control applicable to the laminate capillary-driven microfluidic devices
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影响因子：
6.4
作者：
Koczula KM;Gallotta A
通讯作者：
Gallotta A
影响因子：
6.1
作者：
Elizalde, Emanuel;Urteaga, Raul;Berli, Claudio L. A.
通讯作者：
Berli, Claudio L. A.
影响因子：
4.2
作者：
Cheng, Nian-Sheng
通讯作者：
Cheng, Nian-Sheng
影响因子：
8.4
作者：
Jang, Ilhoon;Berg, Kathleen E.;Henry, Charles S.
通讯作者：
Henry, Charles S.
影响因子：
8.9
作者：
Jang, Ilhoon;Carrao, Daniel B.;Henry, Charles S.
通讯作者：
Henry, Charles S.