Experiences affect social behaviors via altering neuronal morphology and oxytocin system
Experiences affect social behaviors via altering neuronal morphology and oxytocin system
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经历通过改变神经元形态和催产素系统影响社会行为
DOI：
10.1016/j.psyneuen.2021.105247
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发表时间：
2021-04
影响因子：
3.7
通讯作者：
Yuhong Jing
中科院分区：
文献类型：
--
作者：
Fengmei Wei;Wenhao Li;Bo Ma;Xiao Deng;Lang Zhang;Long Zhao;Tingjuan Zheng;Yuhong Jing
生活经历，如母亲剥夺（MD）和环境丰富（EE），会影响成人的社会行为。但是，潜在的机制尚不清楚。在本研究中，我们确定了新生儿MD是否会导致社交缺陷，断奶后EE是否会恢复社交缺陷，以及它们对神经元形态和催产素-催产素受体（OTR）系统的影响。我们发现，情感障碍导致重复行为和新物体识别和社交能力的缺陷，而情感障碍缓解了这些缺陷。MD减少下丘脑室旁大细胞核（mPVH）的催产素能神经元，与基底外侧杏仁核（BLA）的OTR水平和投射神经元树突状分支的增加平行。EE增加了前边缘皮层（PL）和副细胞PVH （vPVH）的OTR水平，这与PL中小锥体神经元树突分支的增加以及BLA和PL中以突触素和突触后密度蛋白95标记的突触连接是平行的。结果表明，断奶后情感表达可减轻新生儿MD所致的社交障碍，OT-OTR系统是经验依赖的，与社交行为和神经元形态有关。
Life experiences, such as maternal deprivation (MD) and environment enrichment (EE), affect social behaviors in the adult. But, the underlying mechanism remains unclear. In the present study, we determined whether neonatal MD induces social deficits, whether postweaning EE restores the deficits, and their effects on neuron morphology and oxytocin (OT)-oxytocin receptor (OTR) system. We found that MD induced repetitive behavior and deficits in novel object recognition and sociability, and EE alleviated these deficits. MD decreased oxytocinergic neurons in the magnocellular hypothalamic paraventricular nucleus (mPVH), which was parallel to the increased OTR levels and dendritic branches of projection neurons in the basolateral amygdala (BLA). EE increased the OTR levels in the prelimbic cortex (PL) and the oxytocinergic neurons in the parvocellular PVH (vPVH), which were parallel to the increased dendritic branches of small pyramidal neurons in the PL and synaptic connections marked with synaptophysin and postsynaptic density protein 95 in the BLA and PL. Together, the results suggest that postweaning EE alleviates the social impairments induced by neonatal MD and OT-OTR system are experience-dependent and associated with social behaviors and neuron morphology.
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影响因子：
64.5
作者：
WIEDENMANN, B;FRANKE, WW
通讯作者：
FRANKE, WW
影响因子：
4.2
作者：
Park AT;Leonard JA;Saxler PK;Cyr AB;Gabrieli JDE;Mackey AP
通讯作者：
Mackey AP
影响因子：
7.4
作者：
Dobolyi A;Cservenák M;Young LJ
通讯作者：
Young LJ
影响因子：
25
作者：
Burgos-Robles A;Kimchi EY;Izadmehr EM;Porzenheim MJ;Ramos-Guasp WA;Nieh EH;Felix-Ortiz AC;Namburi P;Leppla CA;Presbrey KN;Anandalingam KK;Pagan-Rivera PA;Anahtar M;Beyeler A;Tye KM
通讯作者：
Tye KM
DOI：
10.1523/jneurosci.22-18-07840.2002
发表时间：
2002-09
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
D. Francis;J. Diorio;P. Plotsky;M. Meaney
通讯作者：
D. Francis;J. Diorio;P. Plotsky;M. Meaney