Modeling conflict and error in the medial frontal cortex.
Modeling conflict and error in the medial frontal cortex.
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DOI：
10.1002/hbm.21405
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发表时间：
2012-12
影响因子：
4.8
通讯作者：
Jung, Rex E.
中科院分区：
文献类型：
--
作者：
Mayer, Andrew R.;Teshiba, Terri M.;Franco, Alexandre R.;Ling, Josef;Shane, Matthew S.;Stephen, Julia M.;Jung, Rex E.
尽管深入的研究，背内侧额叶皮层（dMFC）在错误监测和冲突处理的作用仍然积极争论。当前的实验操纵冲突类型（刺激冲突或刺激和反应选择冲突），并利用一种新的建模方法来隔离错误和冲突方差在多模态数字Stroop任务。具体而言，血流动力学反应功能产生的两个统计模型，包括或隔离的方差产生的相对较少的错误试验进行了直接对比。24名参与者在1.5特斯拉扫描仪上接受事件相关功能磁共振成像时完成了任务。反应时间单调增加的基础上存在的纯刺激或刺激和反应选择冲突。功能结果表明，在需要反应选择和抑制竞争运动反应的试验期间存在dMFC活性，但在涉及纯刺激冲突的试验期间不存在。不同统计模型的比较表明，相对较少的错误试验导致了不成比例的方差（即，活动），但特别是在喙前扣带回（rACC）。最后，功能连接性分析表明，背侧ACC/前SMA中的经验推导的种子表现出强连接性（即，与前额叶和顶叶下皮层正相关，与缺省模式网络负相关。从rACC的经验得出的种子表现出相反的模式，这表明dMFC的子区域表现出不同的连接模式与其他大规模的网络牵连在内部mentations，如白日梦（默认模式）与执行自上而下的注意力控制（额顶叶）。
Despite intensive study, the role of the dorsal medial frontal cortex (dMFC) in error monitoring and conflict processing remains actively debated. The current experiment manipulated conflict type (stimulus conflict only or stimulus and response selection conflict) and utilized a novel modeling approach to isolate error and conflict variance during a multimodal numeric Stroop task. Specifically, hemodynamic response functions resulting from two statistical models that either included or isolated variance arising from relatively few error trials were directly contrasted. Twenty-four participants completed the task while undergoing event-related functional magnetic resonance imaging on a 1.5-Tesla scanner. Response times monotonically increased based on the presence of pure stimulus or stimulus and response selection conflict. Functional results indicated that dMFC activity was present during trials requiring response selection and inhibition of competing motor responses, but absent during trials involving pure stimulus conflict. A comparison of the different statistical models suggested that relatively few error trials contributed to a disproportionate amount of variance (i.e., activity) throughout the dMFC, but particularly within the rostral anterior cingulate gyrus (rACC). Finally, functional connectivity analyses indicated that an empirically derived seed in the dorsal ACC/pre-SMA exhibited strong connectivity (i.e., positive correlation) with prefrontal and inferior parietal cortex but was anticorrelated with the default-mode network. An empirically derived seed from the rACC exhibited the opposite pattern, suggesting that sub-regions of the dMFC exhibit different connectivity patterns with other large scale networks implicated in internal mentations such as daydreaming (default-mode) versus the execution of top-down attentional control (fronto-parietal).
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
2.9
作者：
Brown, Joshua W.;Braver, Todd S.
通讯作者：
Braver, Todd S.
影响因子：
5.3
作者：
Davis, KD;Taylor, KS;Lozano, AM
通讯作者：
Lozano, AM
DOI：
10.1196/annals.1440.011
发表时间：
2008-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE 2008
影响因子：
--
作者：
Buckner, Randy L.;Andrews-Hanna, Jessica R.;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.
影响因子：
5.7
作者：
Garavan, H;Ross, TJ;Stein, EA
通讯作者：
Stein, EA