The NIH-NIAID Filariasis Research Reagent Resource Center.
The NIH-NIAID Filariasis Research Reagent Resource Center.
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DOI：
10.1371/journal.pntd.0001261
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发表时间：
2011-11
影响因子：
3.8
通讯作者：
Moorhead AR
中科院分区：
文献类型：
--
作者：
Michalski ML;Griffiths KG;Williams SA;Kaplan RM;Moorhead AR
丝虫在人类中引起各种热带疾病;然而，它们很难研究，因为它们具有复杂的生命周期，需要节肢动物中间宿主和哺乳动物最终宿主。工业化国家的研究工作由于某些引起人类疾病的丝虫仅限于对人类的宿主特异性而进一步复杂化。这可能使研究的承诺变得困难，昂贵和限制性。40多年前，美国国立卫生研究院-国家过敏和传染病研究所（NIH-NIAID）建立了一个资源，研究人员可以从中获得各种丝虫寄生虫物种和生命周期阶段，而不必花费必要的精力和资金在自己的实验室中维持整个生命周期。这种集中的资源（丝虫病研究试剂资源中心，或FR3）通过释放拨款的人员成本并允许研究人员将更多资金转移到有针对性的研究目标，从而节省了NIH-NIAID和主要研究人员的成本。许多研究人员，特别是那些新的热带医学领域，不知道的材料和支持的范围由FR3提供。这篇评论旨在提供合同的简短历史，简要描述所提供的fillarial物种和分子资源，并估计资源对研究界的影响，并描述了一些新的补充和潜在的好处资源中心可能为不断变化的研究人员的研究兴趣。
Filarial worms cause a variety of tropical diseases in humans; however, they are difficult to study because they have complex life cycles that require arthropod intermediate hosts and mammalian definitive hosts. Research efforts in industrialized countries are further complicated by the fact that some filarial nematodes that cause disease in humans are restricted in host specificity to humans alone. This potentially makes the commitment to research difficult, expensive, and restrictive. Over 40 years ago, the United States National Institutes of Health–National Institute of Allergy and Infectious Diseases (NIH-NIAID) established a resource from which investigators could obtain various filarial parasite species and life cycle stages without having to expend the effort and funds necessary to maintain the entire life cycles in their own laboratories. This centralized resource (The Filariasis Research Reagent Resource Center, or FR3) translated into cost savings to both NIH-NIAID and to principal investigators by freeing up personnel costs on grants and allowing investigators to divert more funds to targeted research goals. Many investigators, especially those new to the field of tropical medicine, are unaware of the scope of materials and support provided by the FR3. This review is intended to provide a short history of the contract, brief descriptions of the fiilarial species and molecular resources provided, and an estimate of the impact the resource has had on the research community, and describes some new additions and potential benefits the resource center might have for the ever-changing research interests of investigators.
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影响因子：
1.3
作者：
MCCALL, JW
通讯作者：
MCCALL, JW
DOI：
10.1016/0035-9203(67)90162-9
发表时间：
1967-01-01
影响因子：
2.2
作者：
SCHACHER, JF;SAHYOUN, PF
通讯作者：
SAHYOUN, PF
DOI：
10.1080/00034983.1962.11686135
发表时间：
1962-01-01
影响因子：
--
作者：
MACDONALD, WW
通讯作者：
MACDONALD, WW
DOI：
10.1016/0035-9203(60)90089-4
发表时间：
1960-01-01
期刊：
TRANS ROY SOC TROP MED AND HYG
影响因子：
--
作者：
EDESON, J. F. B.;WHARTON, R. H.;LAING, A. B. G.
通讯作者：
LAING, A. B. G.
DOI：
10.1016/0035-9203(58)90112-3
发表时间：
1958-01-01
期刊：
TRANS ROY SOC TROP MED AND HYG
影响因子：
--
作者：
EDESON, J. F. B.;WHARTON, R. H.
通讯作者：
WHARTON, R. H.