High prevalence of screen detected prostate cancer in West Africans: implications for racial disparity of prostate cancer.
High prevalence of screen detected prostate cancer in West Africans: implications for racial disparity of prostate cancer.
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DOI：
10.1016/j.juro.2014.04.017
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发表时间：
2014-09
影响因子：
6.6
通讯作者：
Hoover, Robert N.
中科院分区：
文献类型：
--
作者：
Hsing, Ann W.;Yeboah, Edward;Biritwum, Richard;Tettey, Yao;De Marzo, Angelo M.;Adjei, Andrew;Netto, George J.;Yu, Kai;Li, Yan;Chokkalingam, Anand P.;Chu, Lisa W.;Chia, David;Partin, Alan;Thompson, Ian M.;Quraishi, Sabah M.;Niwa, Shelley;Tarone, Robert;Hoover, Robert N.
据我们所知，美国黑人男性前列腺癌发病率高的原因尚不清楚。遗传和生活方式因素也有牵连。更好地了解西非男性的前列腺癌发病率将有助于澄清为什么美国黑人男性的发病率如此之高，因为这些群体有着共同的遗传祖先，但有着不同的生活方式和筛查实践。为了估计西非男性的前列腺癌负担，我们在加纳进行了一项基于人群的筛查研究，并进行了活检确认。我们从加纳的阿克拉随机选择了1,037名50 - 74岁的健康男性，通过前列腺特异性抗原检测和直肠指检进行前列腺癌筛查。筛查结果阳性（直肠指检阳性或前列腺特异性抗原大于2.5 ng/ml）的男性接受经直肠超声引导活检。在1,037名男性中，154名（14.9%）直肠指检阳性，272名（26.2%）前列腺特异性抗原大于2.5 ng/ml，其中166名前列腺特异性抗原大于4.0 ng/ml。共有352名男性（33.9%）通过前列腺特异性抗原或直肠指检筛查为阳性，307名（87%）接受了活检。在这些男性中，73人被证实患有前列腺癌，筛查检测到的前列腺癌患病率为7.0%（65例患者），其中5.8%的患者前列腺特异性抗原大于4.0 ng/ml。在这个相对未经筛查的非洲人群中，筛查检测到的前列腺癌患病率很高，这表明遗传学在前列腺癌病因学中可能发挥作用，以及美国黑人和白色男性之间前列腺癌风险的差异。需要进一步的研究来证实非洲男性的高前列腺癌负担以及遗传学在前列腺癌病因学中的作用。
To our knowledge the reasons for the high rates of prostate cancer in black American men are unknown. Genetic and lifestyle factors have been implicated. Better understanding of prostate cancer rates in West African men would help clarify why black American men have such high rates since the groups share genetic ancestry and yet have different lifestyles and screening practices. To estimate the prostate cancer burden in West African men we performed a population based screening study with biopsy confirmation in Ghana. We randomly selected 1,037 healthy men 50 to 74 years old from Accra, Ghana for prostate cancer screening with prostate specific antigen testing and digital rectal examination. Men with a positive screen result (positive digital rectal examination or prostate specific antigen greater than 2.5 ng/ml) underwent transrectal ultrasound guided biopsies. Of the 1,037 men 154 (14.9%) had a positive digital rectal examination and 272 (26.2%) had prostate specific antigen greater than 2.5 ng/ml, including 166 with prostate specific antigen greater than 4.0 ng/ml. A total of 352 men (33.9%) had a positive screen by prostate specific antigen or digital rectal examination and 307 (87%) underwent biopsy. Of these men 73 were confirmed to have prostate cancer, yielding a 7.0% screen detected prostate cancer prevalence (65 patients), including 5.8% with prostate specific antigen greater than 4.0 ng/ml. In this relatively unscreened population in Africa the screen detected prostate cancer prevalence is high, suggesting a possible role of genetics in prostate cancer etiology and the disparity in prostate cancer risk between black and white American men. Further studies are needed to confirm the high prostate cancer burden in African men and the role of genetics in prostate cancer etiology.
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DOI：
10.1097/med.0b013e3282febcf6
发表时间：
2008-06-01
影响因子：
3.2
作者：
Chu, Lisa W.;Reichardt, Juergen K. V.;Hsing, Ann W.
通讯作者：
Hsing, Ann W.
中国男性全基因组关联研究确定了 9q31.2 和 19q13.4 两个新的前列腺癌风险位点
影响因子：
30.8
作者：
Xu J;Mo Z;Ye D;Wang M;Liu F;Jin G;Xu C;Wang X;Shao Q;Chen Z;Tao Z;Qi J;Zhou F;Wang Z;Fu Y;He D;Wei Q;Guo J;Wu D;Gao X;Yuan J;Wang G;Xu Y;Wang G;Yao H;Dong P;Jiao Y;Shen M;Yang J;Ou-Yang J;Jiang H;Zhu Y;Ren S;Zhang Z;Yin C;Gao X;Dai B;Hu Z;Yang Y;Wu Q;Chen H;Peng P;Zheng Y;Zheng X;Xiang Y;Long J;Gong J;Na R;Lin X;Yu H;Wang Z;Tao S;Feng J;Sun J;Liu W;Hsing A;Rao J;Ding Q;Wiklund F;Gronberg H;Shu XO;Zheng W;Shen H;Jin L;Shi R;Lu D;Zhang X;Sun J;Zheng SL;Sun Y
通讯作者：
Sun Y
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
6.6
作者：
Smith, DS;Bullock, AD;Herschman, JD
通讯作者：
Herschman, JD
影响因子：
30.8
作者：
Yeager, Meredith;Chatterjee, Nilanjan;Ciampa, Julia;Jacobs, Kevin B.;Gonzalez-Bosquet, Jesus;Hayes, Richard B.;Kraft, Peter;Wacholder, Sholom;Orr, Nick;Berndt, Sonja;Yu, Kai;Hutchinson, Amy;Wang, Zhaoming;Amundadottir, Laufey;Feigelson, Heather Spencer;Thun, Michael J.;Diver, W. Ryan;Albanes, Demetrius;Virtamo, Jarmo;Weinstein, Stephanie;Schumacher, Fredrick R.;Cancel-Tassin, Geraldine;Cussenot, Olivier;Valeri, Antoine;Andriole, Gerald L.;Crawford, E. David;Haiman, Christopher A.;Henderson, Brian;Kolonel, Laurence;Le Marchand, Loic;Siddiq, Afshan;Riboli, Elio;Key, Timothy J.;Kaaks, Rudolf;Isaacs, William;Isaacs, Sarah;Wiley, Kathleen E.;Gronberg, Henrik;Wiklund, Fredrik;Stattin, Par;Xu, Jianfeng;Zheng, S. Lilly;Sun, Jielin;Vatten, Lars J.;Hveem, Kristian;Kumle, Merethe;Tucker, Margaret;Gerhard, Daniela S.;Hoover, Robert N.;Fraumeni, Joseph F., Jr.;Hunter, David J.;Thomas, Gilles;Chanock, Stephen J.
通讯作者：
Chanock, Stephen J.