Feline infectious peritonitis. ABCD guidelines on prevention and management.
Feline infectious peritonitis. ABCD guidelines on prevention and management.
复制标题
DOI：
10.1016/j.jfms.2009.05.008
复制
发表时间：
2009-07
影响因子：
1.7
通讯作者：
Horzinek MC
中科院分区：
文献类型：
--
作者：
Addie D;Belák S;Boucraut-Baralon C;Egberink H;Frymus T;Gruffydd-Jones T;Hartmann K;Hosie MJ;Lloret A;Lutz H;Marsilio F;Pennisi MG;Radford AD;Thiry E;Truyen U;Horzinek MC
猫冠状病毒感染在家猫中普遍存在，在拥挤的地方尤其常见。虽然大多数感染 FCoV 的猫都是健康的或仅表现出轻微的肠炎，但有些猫会继续发展为猫传染性腹膜炎，这种疾病在幼猫和多猫环境中尤其常见。高达 12% 的 FCoV 感染猫可能死于 FIP，压力容易导致疾病的发展。 “湿”或渗出型，以多发性浆膜炎（腹部和/或胸腔积液）和血管炎为特征，“干”或非渗出型（器官中的脓肉芽肿性病变）反映了连续体的临床极端情况。 FIP 的临床表现差异很大，具体取决于血管炎和化脓性肉芽肿病变的分布。抗生素耐药性发烧、嗜睡、厌食和体重减轻是常见的非特异性症状。腹水是渗出型最明显的表现。生前 FIP 的病因学诊断即使不是不可能，也可能很困难。猫的背景、病史、临床体征、实验室变化、抗体滴度和渗出液分析都应用于帮助做出进一步诊断程序的决策。截至撰写本文时，尚无可用于无积液的猫的非侵入性验证测试。在大多数情况下，FIP 是致命的。支持治疗的目的是抑制炎症和有害的免疫反应。然而，没有对照研究证明皮质类固醇有任何有益作用。目前，只有一种（鼻内）FIP 疫苗可用，被认为是非核心疫苗。当小猫尚未接触过 FCoV 时（例如，在早期断奶计划中），特别是当它们进入 FCoV 流行环境时，可能会受益于疫苗接种。
Feline coronavirus infection is ubiquitous in domestic cats, and is particularly common where conditions are crowded. While most FCoV-infected cats are healthy or display only a mild enteritis, some go on to develop feline infectious peritonitis, a disease that is especially common in young cats and multi-cat environments. Up to 12% of FCoV-infected cats may succumb to FIP, with stress predisposing to the development of disease. The ‘wet’ or effusive form, characterised by polyserositis (abdominal and/or thoracic effusion) and vasculitis, and the ‘dry’ or non-effusive form (pyogranulomatous lesions in organs) reflect clinical extremes of a continuum. The clinical picture of FIP is highly variable, depending on the distribution of the vasculitis and pyogranulomatous lesions. Fever refractory to antibiotics, lethargy, anorexia and weight loss are common non-specific signs. Ascites is the most obvious manifestation of the effusive form. The aetiological diagnosis of FIP ante-mortem may be difficult, if not impossible. The background of the cat, its history, the clinical signs, laboratory changes, antibody titres and effusion analysis should all be used to help in decision-making about further diagnostic procedures. At the time of writing, there is no non-invasive confirmatory test available for cats without effusion. In most cases FIP is fatal. Supportive treatment is aimed at suppressing the inflammatory and detrimental immune response. However, there are no controlled studies to prove any beneficial effect of corticosteroids. At present, only one (intranasal) FIP vaccine is available, which is considered as being non-core. Kittens may profit from vaccination when they have not been exposed to FCoV (eg, in an early-weaning programme), particularly if they enter a FCoV-endemic environment.
登录
查看更多内容
影响因子：
3.3
作者：
Cornelissen, E.;Dewerchin, H. L.;Nauwynck, H. J.
通讯作者：
Nauwynck, H. J.
影响因子：
2.2
作者：
Duthie, S;Eckersall, PD;Jarrett, O
通讯作者：
Jarrett, O
影响因子：
5.4
作者：
Haagmans, BL;Egberink, HF;Horzinek, MC
通讯作者：
Horzinek, MC
影响因子：
5.5
作者：
GERBER, JD;INGERSOLL, JD;BECKENHAUER, WH
通讯作者：
BECKENHAUER, WH
影响因子：
1.8
作者：
Gunn-Moore, DA;Caney, SMA;Harbour, DA
通讯作者：
Harbour, DA