Polymer-Based Surfaces Designed to Reduce Biofilm Formation: From Antimicrobial Polymers to Strategies for Long-Term Applications.
Polymer-Based Surfaces Designed to Reduce Biofilm Formation: From Antimicrobial Polymers to Strategies for Long-Term Applications.
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DOI：
10.1002/marc.201700216
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发表时间：
2017-10
影响因子：
4.6
通讯作者：
Lienkamp K
中科院分区：
文献类型：
--
作者：
Riga EK;Vöhringer M;Widyaya VT;Lienkamp K
接触活性抗微生物聚合物表面带有阳离子电荷，并通过与其细胞包膜的带负电荷部分（脂多糖、肽聚糖和膜脂质）相互作用杀死或灭活细菌。这种相互作用的确切机制仍在争论中。虽然阳离子抗微生物聚合物表面对于短期应用非常有用，但是一旦它们被足够厚的粘附生物分子或细菌细胞碎片层污染，它们就失去了活性。该层保护进入的细菌免受抗微生物活性阳离子表面部分的影响。除了讨论抗菌表面，这篇专题文章还重点介绍了为克服污染问题而开发的最新策略。这包括具有同时存在的抗微生物和蛋白质排斥部分的双功能材料;可以从抗微生物、细胞吸引状态转换为细胞排斥状态的聚合物表面;可以通过酶作用再生的聚合物表面;可降解的抗微生物聚合物;以及具有可移除顶层的抗微生物聚合物表面。
Contact-active antimicrobial polymer surfaces bear cationic charges and kill or deactivate bacteria by interaction with the negatively charged parts of their cell envelope (lipopolysaccharides, peptidoglycan, and membrane lipids). The exact mechanism of this interaction is still under debate. While cationic antimicrobial polymer surfaces can be very useful for short term applications, they lose their activity once they get contaminated by a sufficiently thick layer of adhering biomolecules or bacterial cell debris. This layer shields incoming bacteria from the antimicrobially active cationic surface moieties. Besides discussing antimicrobial surfaces, this feature article focuses on recent strategies that were developed to overcome the contamination problem. This includes bifunctional materials with simultaneously presented antimicrobial and protein-repellent moieties; polymer surfaces which can be switched from an antimicrobial, cell-attractive to a cell-repellent state; polymer surfaces that can be regenerated by enzyme action; degradable antimicrobial polymers; and antimicrobial polymer surfaces with removable top layers.
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作者：
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通讯作者：
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影响因子：
4.6
作者：
Bieser, Arno M.;Tiller, Joerg C.
通讯作者：
Tiller, Joerg C.