A mixed-effects model approach for the statistical analysis of vocal fold viscoelastic shear properties.
A mixed-effects model approach for the statistical analysis of vocal fold viscoelastic shear properties.
复制标题
用于声带粘弹性剪切特性统计分析的混合效应模型方法。
DOI：
10.1016/j.jmbbm.2017.08.006
复制
发表时间：
2017
影响因子：
3.9
通讯作者：
Zhan,Xiaowei
中科院分区：
文献类型：
--
作者：
Xu,ChetC;Chan,RogerW;Sun,Han;Zhan,Xiaowei
在这项研究中引入了一种混合效应模型方法，用于声带组织流变学数据的统计分析，以解释在测试频率范围内对每个组织样本进行多次测量所引起的数据相关性。在过去几十年的研究中，这种数据相关性往往被忽视。用线性可控应变单剪流变仪测定了两种常用喉部研究动物（即兔、猪）声带固有层的粘弹性剪切特性。沿着已发表的犬和人流变学数据，使用混合效应模型在1-250 Hz的频率范围内将这些动物物种的声带粘弹性剪切模量与人的声带粘弹性剪切模量进行比较。我们的研究结果表明，兔，犬和猪的声带固有层的组织显着更硬，更粘比人。混合效应模型被证明能够更准确地分析从重复测量产生的流变数据。
A mixed-effects model approach was introduced in this study for the statistical analysis of rheological data of vocal fold tissues, in order to account for the data correlation caused by multiple measurements of each tissue sample across the test frequency range. Such data correlation had often been overlooked in previous studies in the past decades. The viscoelastic shear properties of the vocal fold lamina propria of two commonly used laryngeal research animal species (i.e. rabbit, porcine) were measured by a linear, controlled-strain simple-shear rheometer. Along with published canine and human rheological data, the vocal fold viscoelastic shear moduli of these animal species were compared to those of human over a frequency range of 1–250 Hz using the mixed-effects models. Our results indicated that tissues of the rabbit, canine and porcine vocal fold lamina propria were significantly stiffer and more viscous than those of human. Mixed-effects models were shown to be able to more accurately analyze rheological data generated from repeated measurements.
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DOI：
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发表时间：
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期刊：
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